EDS1 signalling: At the nexus of intracellular and surface receptor immunity.
Autor: | Dongus JA; Department of Plant-Microbe Interactions, Max-Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, Cologne, 50829, Germany., Parker JE; Cologne-Düsseldorf Cluster of Excellence on Plant Sciences (CEPLAS), 40225, Düsseldorf, Germany; Department of Plant-Microbe Interactions, Max-Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, Cologne, 50829, Germany. Electronic address: parker@mpipz.mpg.de. |
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Jazyk: | angličtina |
Zdroj: | Current opinion in plant biology [Curr Opin Plant Biol] 2021 Aug; Vol. 62, pp. 102039. Date of Electronic Publication: 2021 Apr 27. |
DOI: | 10.1016/j.pbi.2021.102039 |
Abstrakt: | The conserved lipase-like protein EDS1 transduces signals from pathogen-activated intracellular nucleotide-binding leucine-rich repeat (NLR) receptors to transcriptional defences and host cell death. In this pivotal NLR signalling role, EDS1 works as a heterodimer with each of its partners, SAG101 and PAD4. Different properties of EDS1-SAG101 and EDS1-PAD4 complexes and functional relationships to sensor and helper NLRs have emerged. EDS1-SAG101 dimers confer effector-triggered immunity mediated by intracellular TNL receptors. In contrast, EDS1-PAD4 dimers have a broader role promoting basal immune responses that can be initiated inside cells by TNL- or CNL-type NLRs, and at the cell surface by LRR-receptor proteins. Characterizing the essential elements of these two EDS1 modules will help to connect intracellular and surface receptor signalling networks in the plant immune system. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
Databáze: | MEDLINE |
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