Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process.

Autor: do Carmo Neto JR; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil., Braga YLL; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil., da Costa AWF; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil., Lucio FH; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil., do Nascimento TC; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil., Dos Reis MA; Department of General Pathology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil., Celes MRN; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil., de Oliveira FA; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil., Machado JR; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil.; Department of General Pathology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil., da Silva MV; Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
Jazyk: angličtina
Zdroj: Journal of immunology research [J Immunol Res] 2021 Apr 07; Vol. 2021, pp. 6668739. Date of Electronic Publication: 2021 Apr 07 (Print Publication: 2021).
DOI: 10.1155/2021/6668739
Abstrakt: The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Trypanosoma cruzi . Components such as neuronal subpopulations, enteric glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding of the association between T. cruzi infection and immune, endocrine, and neurological system changes.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this review article.
(Copyright © 2021 José Rodrigues do Carmo Neto et al.)
Databáze: MEDLINE
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