[Allergic Broncho-Pulmonary Aspergillosis (ABPA) in cystic fibrosis: Mechanisms, diagnosis and therapeutic options].

Autor:	Bui S; CRCM pédiatrique, Centre d'investigation clinique (CIC 1401), hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux, France. Electronic address: stephanie.bui@chu-bordeaux.fr., Dournes G; Service de radiologie, hôpital Haut L'Evêque, CHU de Bordeaux, Bordeaux, France., Fayon M; CRCM pédiatrique, Centre d'investigation clinique (CIC 1401), hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux, France., Bouchet S; Service de pharmacologie, hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France., Burgel PR; CRCM Adultes, AP-HP, hôpital Cochin, Paris, France., Macey J; CRCM adultes, hôpital Haut L'Evêque, CHU de Bordeaux, Bordeaux, France., Murris M; CRCM adultes, hôpital Larrey, CHU de Toulouse, Toulouse, France., Delhaes L; Service de parasitologie, CHU de Bordeaux, hôpital Pellegrin, Bordeaux, France.
Jazyk:	francouzština
Zdroj:	Revue des maladies respiratoires [Rev Mal Respir] 2021 May; Vol. 38 (5), pp. 466-476. Date of Electronic Publication: 2021 Apr 27.
DOI:	10.1016/j.rmr.2021.04.004
Abstrakt:	Introduction: Fungal aspergillosis colonization and allergic bronchopulmonary aspergillosis (ABPA) can have a strong impact on the prognosis in cystic fibrosis (CF). We conducted round table discussions involving French experts from pediatric and adult centers caring for patients with CF, microbiologists, radiologists and pharmacists. The aim was to explore the current state of knowledge on: the pathophysiological mechanisms of Aspergillus and other micromycetes infections in CF (such as Scedosporium sp.), and on the clinico-biological diagnosis of ABPA. In perspective, the experts explored the role of imaging in the diagnosis of APBA, specifically CT and MRI; as well as the role of bronchoscopy in the management. We also reviewed the therapeutic management, including different corticosteroid regimens, antifungals and anti-IgE antibodies. Conclusion: The diagnosis of ABPA in CF should be based on more standardized biological assays and imaging to optimize treatment and follow-up. (Copyright © 2021 SPLF. Published by Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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