Adult rats from undernourished dams show sex-dependent impaired expression in taste papillae and hypothalamus of genes responsible for sweet and fat detection and signalling.

Autor: Olvera Hernández S; UMR Physiologie des Adaptations Nutritionnelles, INRAE - Université de Nantes, 44096 Nantes France., Reyes Castro LA; UMR Physiologie des Adaptations Nutritionnelles, INRAE - Université de Nantes, 44096 Nantes France.; Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México., Daher Abdi A; UMR Physiologie des Adaptations Nutritionnelles, INRAE - Université de Nantes, 44096 Nantes France., Mezo-González CE; UMR Physiologie des Adaptations Nutritionnelles, INRAE - Université de Nantes, 44096 Nantes France., Arredondo A; National Institute of Public Health, Cuernavaca, Morelos, México., Zambrano E; Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México., Bolaños-Jiménez F; UMR Physiologie des Adaptations Nutritionnelles, INRAE - Université de Nantes, 44096 Nantes France.
Jazyk: angličtina
Zdroj: Nutritional neuroscience [Nutr Neurosci] 2022 Oct; Vol. 25 (10), pp. 2011-2022. Date of Electronic Publication: 2021 Apr 30.
DOI: 10.1080/1028415X.2021.1920678
Abstrakt: Aim: Individuals undernourished in utero or during early life are at high risk of developing obesity and metabolic disorders and show an increased preference for consuming sugary and fatty food. This study aimed at determining whether impaired taste detection and signalling in the lingual epithelium and the brain might contribute to this altered pattern of food intake.
Methods: The preference for feeding fat and sweet food and the expression in circumvallate papillae and hypothalamus of genes coding for sweet and fat receptors and transducing pathways were evaluated in adult rats born to control or calorie-restricted dams. Expression in the hypothalamus and the brain's reward system of genes involved in the homeostatic and hedonic control of food intake was also determined.
Results: Male and female undernourished animals exhibited increased expression in taste papillae and hypothalamus of T1R1, T1R2, CD36, gustducin, TRMP5 and PLC-β2 genes, all of which modulate sweet and fat detection and intracellular signalling. However, the severity of the effect was greater in females than in males. Moreover, male, but not female, undernourished rats consumed more standard and sweetened food than their control counterparts and presented increased hypothalamic AgRP and NPY mRNAs levels together with enhanced dopamine transporter and dopamine receptor D2 expression in the ventral tegmental area.
Conclusions: Maternal undernutrition induces sex-specific changes in food preferences and gene expression in taste papillae, hypothalamus and brain reward regions. The gene expression alterations in the male offspring are in line with their preference for consuming sugary and fatty food.
Databáze: MEDLINE
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