| Autor: |
Skalny AV; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.; Laboratory of Medical Elementology, KG Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia., Timashev PS; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.; Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.; Department of Polymers and Composites, N.N. Semenov Institute of Chemical Physics, 119991 Moscow, Russia., Aschner M; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Aaseth J; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.; Research Department, Innlandet Hospital Trust, 2380 Brumunddal, Norway., Chernova LN; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia., Belyaev VE; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia., Grabeklis AR; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia., Notova SV; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.; Institute of Bioelementology, Orenburg State University, 460018 Orenburg, Russia., Lobinski R; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.; l'Institut des Sciences Analytiques et de Physico-chimie pour l'Environnement et les Matériaux, Universite de Pau et des Pays de l'Adour, E2S, CNRS, 64000 Pau, France., Tsatsakis A; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.; Laboratory of Toxicology, Medical School, University of Crete, Voutes, 70013 Heraklion, Crete, Greece., Svistunov AA; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia., Fomin VV; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia., Tinkov AA; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.; Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, 150003 Yaroslavl, Russia., Glybochko PV; World-Class Research Center 'Digital Biodesign and Personalized Healthcare', IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia. |
| Abstrakt: |
The objective of the present study was to evaluate of serum metal levels in COVID-19 patients with different disease severity, and to investigate the independent association between serum metal profile and markers of lung damage. The cohort of COVID-19 patients consisted of groups of subjects with mild, moderate, and severe illness, 50 examinees each. Forty-four healthy subjects of the respective age were involved in the current study as the control group. Serum metal levels were evaluated using inductively-coupled plasma mass-spectrometry. Examination of COVID-19 patients demonstrated that heart rate, respiratory rate, body temperature, C-reactive protein levels, as well as lung damage increased significantly with COVID-19 severity, whereas SpO 2 decreased gradually. Increasing COVID-19 severity was also associated with a significant gradual decrease in serum Ca, Fe, Se, Zn levels as compared to controls, whereas serum Cu and especially Cu/Zn ratio were elevated. No significant group differences in serum Mg and Mn levels were observed. Serum Ca, Fe, Se, Zn correlated positively with SpO 2 , being inversely associated with fever, lung damage, and C-reactive protein concentrations. Opposite correlations were observed for Cu and Cu/Zn ratio. In regression models, serum Se levels were inversely associated with lung damage independently of other markers of disease severity, anthropometric, biochemical, and hemostatic parameters. Cu/Zn ratio was also considered as a significant predictor of lower SpO 2 in adjusted regression models. Taken together, these findings demonstrated that metal metabolism significantly interferes with COVID-19 pathogenesis, although the causal relations as well as precise mechanisms are yet to be characterized. |
