Potential Impact of Statins on Neuronal Stress Responses in Patients at Risk for Cardiovascular Disease.

Autor:	Diggelmann F; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Bengs S; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Haider A; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Epprecht G; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Beeler AL; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Etter D; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Wijnen WJ; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Portmann A; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Warnock GI; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Treyer V; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Grämer M; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Todorov A; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Mikail N; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Rossi A; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Fuchs TA; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Pazhenkottil AP; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Buechel RR; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Tanner FC; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland.; Department of Cardiology, University of Zurich, 8091 Zurich, Switzerland., Kaufmann PA; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Gebhard C; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland., Fiechter M; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland.; Swiss Paraplegic Center, 6207 Nottwil, Switzerland.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2021 Apr 01; Vol. 11 (4). Date of Electronic Publication: 2021 Apr 01.
DOI:	10.3390/jpm11040261
Abstrakt:	Background: Recent studies indicate that enhanced neuronal stress responses are associated with adverse cardiovascular outcomes. A chronic inflammatory state seems to mediate this detrimental neuro-cardiac communication. Statins are among the most widely prescribed medications in primary and secondary cardiovascular disease (CVD) prevention and not only lower lipid levels but also exhibit strong anti-inflammatory and neuroprotective effects. We therefore sought to investigate the influence of statins on neuronal stress responses in a patient cohort at risk for CVD. Methods: 563 patients (61.5 ± 14.0 years) who underwent echocardiography and 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) were retrospectively identified. Metabolic activity of the amygdala, a part of the brain's salience network, was quantified by 18 F-FDG uptake, while normal cardiac morphology and function were assured by echocardiography. Vertebral bone marrow metabolism, a marker of inflammatory activity, was measured by 18 F-FDG PET. Results: Increased neuronal stress responses were associated with an increased inflammatory activity in the bone marrow (r = 0.152, p = 0.015) as well as with a subclinical reduction in left ventricular ejection fraction (LVEF, r = -0.138, p = 0.025). In a fully-adjusted linear regression model, statin treatment was identified as an independent, negative predictor of amygdalar metabolic activity (B-coefficient -0.171, p = 0.043). Conclusions: Our hypothesis-generating investigation suggests a potential link between the anti-inflammatory actions of statins and reduced neuronal stress responses which could lead to improved cardiovascular outcomes. The latter warrants further studies in a larger and prospective population.
Databáze:	MEDLINE
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