The 1 H, 15 N, and 13 C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus.

Autor: de Araujo TS; Protein Advanced Biochemistry (PAB), Institute of Medical Biochemistry (IBqM)-National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil., Barbosa GM; National Center of Nuclear Magnetic Resonance (CNRMN), Institute of Medical Biochemistry (IBqM)-Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil., Sanches K; National Center of Nuclear Magnetic Resonance (CNRMN), Institute of Medical Biochemistry (IBqM)-Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil., Azevedo JM; Protein Advanced Biochemistry (PAB), Institute of Medical Biochemistry (IBqM)-National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil., Dos Santos Cabral KM; Protein Advanced Biochemistry (PAB), Institute of Medical Biochemistry (IBqM)-National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil., Almeida MS; Protein Advanced Biochemistry (PAB), Institute of Medical Biochemistry (IBqM)-National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil., Almeida FCL; National Center of Nuclear Magnetic Resonance (CNRMN), Institute of Medical Biochemistry (IBqM)-Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. falmeida@bioqmed.ufrj.br.; Rio BioNMR Network (RMNRio), Rio de Janeiro, Brazil. falmeida@bioqmed.ufrj.br.
Jazyk: angličtina
Zdroj: Biomolecular NMR assignments [Biomol NMR Assign] 2021 Oct; Vol. 15 (2), pp. 341-345. Date of Electronic Publication: 2021 Apr 29.
DOI: 10.1007/s12104-021-10027-6
Abstrakt: During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcriptional regulatory sequence (TRS) and is involved in the discontinuous transcription through the melting activity of double-stranded TRS (dsTRS).
(© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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