Local and Systemic Factors Drive Ectopic Osteogenesis in Regenerating Muscles of Spinal-Cord-Injured Mice in a Lesion-Level-Dependent Manner.

Autor:	Debaud C; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.; Spine Division, Orthopaedic Surgery Department, Queensland Health, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.; Université de Versailles Saint Quentin en Yvelines, U1179 INSERM, UFR des Sciences de la Santé-Simone Veil, Montigny-le-Bretonneux, France.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Saint Lucia, Queensland, Australia., Tseng HW; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia., Chedik M; Université de Versailles Saint Quentin en Yvelines, U1179 INSERM, UFR des Sciences de la Santé-Simone Veil, Montigny-le-Bretonneux, France., Kulina I; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia., Genêt F; Université de Versailles Saint Quentin en Yvelines, U1179 INSERM, UFR des Sciences de la Santé-Simone Veil, Montigny-le-Bretonneux, France.; Service de Réhabilitation, Hôpital Raymond Poincaré, APHP, CIC-IT 1429, Garches, France., Ruitenberg MJ; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Saint Lucia, Queensland, Australia., Levesque JP; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.
Jazyk:	angličtina
Zdroj:	Journal of neurotrauma [J Neurotrauma] 2021 Aug 01; Vol. 38 (15), pp. 2162-2175. Date of Electronic Publication: 2021 Jun 18.
DOI:	10.1089/neu.2021.0058
Abstrakt:	Neuroimmune dysfunction is thought to promote the development of several acute and chronic complications in spinal cord injury (SCI) patients. Putative roles for adrenal stress hormones and catecholamines are increasingly being recognized, yet how these adversely affect peripheral tissue homeostasis and repair under SCI conditions remains elusive. Here, we investigated their influence in a mouse model of SCI with acquired neurogenic heterotopic ossification. We show that spinal cord lesions differentially influence muscular regeneration in a level-dependent manner and through a complex multi-step process that creates an osteopermissive environment within the first hours of injury. This cascade of events is shown to critically involve adrenergic signals and drive the acute release of the neuropeptide, substance P. Our findings generate new insights into the kinetics and processes that govern SCI-induced deregulations in skeletal muscle homeostasis and regeneration, thereby aiding the development of sequential therapeutic strategies that can prevent or attenuate neuromusculoskeletal complications in SCI patients.
Databáze:	MEDLINE
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