Enhanced Fiber Tractography Using Edema Correction: Application and Evaluation in High-Grade Gliomas.

Autor:	Henderson F Jr; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Neurosurgery, The Medical University of South Carolina, Charleston, South Carolina, USA., Parker D; DiCIPHR (Diffusion and Connectomics in Precision Healthcare Research) Lab, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Vijayakumari AA; DiCIPHR (Diffusion and Connectomics in Precision Healthcare Research) Lab, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Elliott M; Center for Magnetic Resonance and Optical Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lucas T; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., McGarvey ML; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Karpf L; Neuroradiology Clinical Research Division, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Desiderio L; Neuroradiology Clinical Research Division, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Harsch J; Neurosurgery Clinical Research Division, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Levy S; Neurosurgery Clinical Research Division, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Maloney-Wilensky E; Neurosurgery Clinical Research Division, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wolf RL; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Hodges WB; Synaptive Medical Inc, Toronto, Canada., Brem S; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Verma R; DiCIPHR (Diffusion and Connectomics in Precision Healthcare Research) Lab, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Departments of Neurosurgery and Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	Neurosurgery [Neurosurgery] 2021 Jul 15; Vol. 89 (2), pp. 246-256.
DOI:	10.1093/neuros/nyab129
Abstrakt:	Background: A limitation of diffusion tensor imaging (DTI)-based tractography is peritumoral edema that confounds traditional diffusion-based magnetic resonance metrics. Objective: To augment fiber-tracking through peritumoral regions by performing novel edema correction on clinically feasible DTI acquisitions and assess the accuracy of the fiber-tracks using intraoperative stimulation mapping (ISM), task-based functional magnetic resonance imaging (fMRI) activation maps, and postoperative follow-up as reference standards. Methods: Edema correction, using our bi-compartment free water modeling algorithm (FERNET), was performed on clinically acquired DTI data from a cohort of 10 patients presenting with suspected high-grade glioma and peritumoral edema in proximity to and/or infiltrating language or motor pathways. Deterministic fiber-tracking was then performed on the corrected and uncorrected DTI to identify tracts pertaining to the eloquent region involved (language or motor). Tracking results were compared visually and quantitatively using mean fiber count, voxel count, and mean fiber length. The tracts through the edematous region were verified based on overlay with the corresponding motor or language task-based fMRI activation maps and intraoperative ISM points, as well as at time points after surgery when peritumoral edema had subsided. Results: Volume and number of fibers increased with application of edema correction; concordantly, mean fractional anisotropy decreased. Overlay with functional activation maps and ISM-verified eloquence of the increased fibers. Comparison with postsurgical follow-up scans with lower edema further confirmed the accuracy of the tracts. Conclusion: This method of edema correction can be applied to standard clinical DTI to improve visualization of motor and language tracts in patients with glioma-associated peritumoral edema. (© Congress of Neurological Surgeons 2021.)
Databáze:	MEDLINE
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