Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection.

Autor:	Pacheco-Herrero M; Neuroscience Research Laboratory, Faculty of Health Sciences, Pontificia Universidad Católica Madre y Maestra, Santiago de los Caballeros, Dominican Republic., Soto-Rojas LO; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Mexico City, Mexico., Harrington CR; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom., Flores-Martinez YM; Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City, Mexico., Villegas-Rojas MM; Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politécnico Nacional (UPIBI- IPN), Mexico City, Mexico., León-Aguilar AM; Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politécnico Nacional (UPIBI- IPN), Mexico City, Mexico., Martínez-Gómez PA; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Mexico City, Mexico., Campa-Córdoba BB; Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.; National Dementia BioBank, Ciencias Biológicas, Facultad de Estudios Superiores, Cuautitlán, Mexico., Apátiga-Pérez R; Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.; National Dementia BioBank, Ciencias Biológicas, Facultad de Estudios Superiores, Cuautitlán, Mexico., Corniel-Taveras CN; Neuroscience Research Laboratory, Faculty of Health Sciences, Pontificia Universidad Católica Madre y Maestra, Santiago de los Caballeros, Dominican Republic., Dominguez-García JJ; Neuroscience Research Laboratory, Faculty of Health Sciences, Pontificia Universidad Católica Madre y Maestra, Santiago de los Caballeros, Dominican Republic., Blanco-Alvarez VM; Facultad de Enfermeria, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico., Luna-Muñoz J; National Dementia BioBank, Ciencias Biológicas, Facultad de Estudios Superiores, Cuautitlán, Mexico.; Banco Estado de Cerebros-UNPHU, Universidad Nacional Pedro Henriquez Ureña, Santo Domingo, Dominican Republic.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2021 Apr 12; Vol. 12, pp. 660087. Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
DOI:	10.3389/fneur.2021.660087
Abstrakt:	The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of evidence suggest that SARS-CoV-2 may affect the central nervous system (CNS) and cause neurological symptoms in COVID-19 patients. It is also known that angiotensin-converting enzyme-2 (ACE2), the primary receptor for SARS-CoV-2 infection, is expressed in different brain areas and cell types. Thus, it is hypothesized that infection by this virus could generate or exacerbate neuropathological alterations. However, the molecular mechanisms that link COVID-19 disease and nerve damage are unclear. In this review, we describe the routes of SARS-CoV-2 invasion into the central nervous system. We also analyze the neuropathologic mechanisms underlying this viral infection, and their potential relationship with the neurological manifestations described in patients with COVID-19, and the appearance or exacerbation of some neurodegenerative diseases. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Pacheco-Herrero, Soto-Rojas, Harrington, Flores-Martinez, Villegas-Rojas, León-Aguilar, Martínez-Gómez, Campa-Córdoba, Apátiga-Pérez, Corniel-Taveras, Dominguez-García, Blanco-Alvarez and Luna-Muñoz.)
Databáze:	MEDLINE
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