Murine Double Minute 2 Gene ( MDM2 ) rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women.

Autor:	Shebli WTY; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia., Alotibi MKH; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia., Al-Raddadi RI; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia., Al-Amri RJ; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia., Fallatah EIY; Department of Oncology, King Fahad Hospital, Madinah, Saudi Arabia., Alhujaily AS; Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia., Mohamed HS; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia.; Institute of Endemic Diseases, University of Khartoum, Sudan.
Jazyk:	angličtina
Zdroj:	Saudi journal of biological sciences [Saudi J Biol Sci] 2021 Apr; Vol. 28 (4), pp. 2272-2277. Date of Electronic Publication: 2021 Jan 21.
DOI:	10.1016/j.sjbs.2021.01.020
Abstrakt:	Breast cancer is predominant causes of mortality in women worldwide. Genetic polymorphisms have a significant role in breast cancer aetiology. TP53 and its inhibitor the murine double minute 2 (MDM2 ) genes encode proteins that have crucial functions in the DNA damage response. The allelic variations within these genes could influence the susceptibility to breast cancer. MDM2 promotor polymorphism rs937283A/G has a role in susceptibility to cancer and modifies the promoter activity. In the present case-control study, the association of MDM2 rs937283A/G polymorphism and breast cancer susceptibility in Saudi women with samples of 137 breast cancer patients, and 98 healthy controls were explored. MDM2 gene polymorphism rs937283A/G was genotyped by polymerase chain reaction restriction fragment length polymorphism and confirmed by sequencing. The results revealed that rs937283A/G variant is significantly increases the risk of breast cancer in Saudi women (p-value = 0.0078). Moreover, rs937283A/G polymorphism was associated with high risk of breast cancer in estrogen positive breast cancer patients (p-value = 0.0088), progesterone positive breast cancer patients (p-value = 0.0043), human epidermal growth factor receptor 2 negative breast cancer patients (p-value = 0.0026), and triple negative breast cancer patients where (p-value = 0.0003). Positive association between increased breast cancer risk and rs937283 variant in premenopausal Saudi women, below 50 years of age, was demonstrated (p-value = 0.0023). Collectively, MDM2 rs937283A/G polymorphism could act as a possible biomarker for breast cancer susceptibility in Saudi women. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Author(s).)
Databáze:	MEDLINE
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