The hypothalamus predates the origin of vertebrates.
| Autor: | Lemaire LA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Cao C; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Yoon PH; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Long J; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Levine M; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. msl2@princeton.edu.; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Science advances [Sci Adv] 2021 Apr 28; Vol. 7 (18). Date of Electronic Publication: 2021 Apr 28 (Print Publication: 2021). |
| DOI: | 10.1126/sciadv.abf7452 |
| Abstrakt: | The hypothalamus coordinates neuroendocrine functions in vertebrates. To explore its evolutionary origin, we describe integrated transcriptome/connectome brain maps for swimming tadpoles of Ciona , which serves as an approximation of the ancestral proto-vertebrate. This map features several cell types related to different regions of the vertebrate hypothalamus, including the mammillary nucleus, the arcuate nucleus, and magnocellular neurons. Coronet cells express melanopsin and share additional properties with the saccus vasculosus, a specialized region of the hypothalamus that mediates photoperiodism in nontropical fishes. Comparative transcriptome analyses identified orthologous cell types for mechanosensory switch neurons, and VP + and VPR + relay neurons in different regions of the mouse hypothalamus. These observations provide evidence that the hypothalamus predates the evolution of the vertebrate brain. We discuss the possibility that switch neurons, coronet cells, and FoxP + / VPR + relay neurons comprise a behavioral circuit that helps trigger metamorphosis of Ciona larvae in response to twilight. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).) |
| Databáze: | MEDLINE |
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