Evaluation of oxidative stress markers in hospitalized patients with moderate and severe COVID-19.

Autor:	Zendelovska D; University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, Republic of North Macedonia., Atanasovska E; University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, Republic of North Macedonia., Petrushevska M; University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, Republic of North Macedonia., Spasovska K; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of North Macedonia., Stevanovikj M; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of North Macedonia., Demiri I; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of North Macedonia., Labachevski N; University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, Republic of North Macedonia.
Jazyk:	angličtina
Zdroj:	Romanian journal of internal medicine = Revue roumaine de medecine interne [Rom J Intern Med] 2021 Nov 20; Vol. 59 (4), pp. 375-383. Date of Electronic Publication: 2021 Nov 20 (Print Publication: 2021).
DOI:	10.2478/rjim-2021-0014
Abstrakt:	Background. Clinical evidence suggests increased oxidative stress in COVID-19 patients and this worsened redox status could potentially contribute to the progression of the disease. Objectives. To investigate the oxidative stress we have measured oxidative stress parameters, namely, PAT (total antioxidant power, iron reducing) and d-ROMs (plasma peroxides). Additionally we have investigated their correlation with the most frequently used clinical parameters CRP, LDH, and NLR in serum from moderate and severe COVID-19 patients hospitalized in a tertiary hospital. Methods. PAT and d-ROMs were determined by analytical photometric metric method in serum from 50 hospitalized patients. For each of them, two samples were collected and analyzed immediately after collection seven days apart. Results. All patients at admission had a much higher value for plasma peroxides and a significant correlation between oxidative stress parameters and CRP, LDH, and NLR. (p<0.05), except for OS index (OSI) vs CRP in the severe group. At discharge, plasma peroxides were reduced and OSI was improved in the moderate group. Conclusion. We consider that using OSI at the beginning of COVID-19 disease presents a valuable starting point for the general assessment of oxidative stress and hence enabling a better triage of the patients in terms of disease severity. (© 2021 Dragica Zendelovska et al., published by Sciendo.)
Databáze:	MEDLINE
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