Discharge characteristics of neurons of nucleus reuniens across sleep-wake states in the behaving rat.

Autor: Viena TD; Department of Psychology, Florida International University, Miami, FL, 33199, United States; Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL, 33431, United States., Vertes RP; Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL, 33431, United States; Department of Psychology, Florida Atlantic University, Boca Raton, FL, 33431, United States. Electronic address: rvertes@fau.edu., Linley SB; Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL, 33431, United States.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2021 Jul 23; Vol. 410, pp. 113325. Date of Electronic Publication: 2021 Apr 25.
DOI: 10.1016/j.bbr.2021.113325
Abstrakt: The nucleus reuniens (RE) of the ventral midline thalamus is strongly reciprocally connected with the hippocampus (HF) and medial prefrontal cortex (PFC), serving a critical role in affective and cognitive functioning. While midline thalamic nuclei have been implicated in the modulation of states of arousal and consciousness, few studies have addressed RE's role in behavioral state control. Accordingly, as a first line of investigation, we examined the discharge properties of RE neurons in behaving rats throughout the sleep-wake cycle. We analyzed 153 units in RE which demonstrated heterogeneity in discharge rates and pattern of activity across sleep wake states. Using a rate ratio of activity in wake vs. REM, we found that the majority of cells displayed state-related changes and were classified into distinct cell types, exhibiting their highest discharge rates during active waking (AW), REM sleep, or maintaining equivalent activity across AW/REM. We further distinguished cells as either slow firing (SF = < 10 Hz) or fast firing (FF =>10 Hz) cells. The majority of cells, independent of state-related preference, were SF. FF RE cells were primarily wake active and wake/REM cell types. This diverse set of RE neurons are likely modulated by key brainstem and hypothalamic nuclei, which in turn, drive RE to exert strong effects on its cortical targets during waking and REM sleep. RE may not only act as a node in HF-PFC circuitry, but also as a critical thalamic link in ascending arousal and attentional networks.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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