[Expression of hypoxia inducible factor-1alpha during mouse mandibular first molar eruption and its significance].

Autor:	Hu X; Department of Oral and Maxillofacial Surgery, School ＆ Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration. Shanghai 200072, China. E-mail:linchenguanlu@163.com., Kang FW
Jazyk:	čínština
Zdroj:	Shanghai kou qiang yi xue = Shanghai journal of stomatology [Shanghai Kou Qiang Yi Xue] 2021 Feb; Vol. 30 (1), pp. 13-16.
Abstrakt:	Purpose: To investigate the expression of hypoxia inducible factor-1alpha (HIF-1α) during the eruption of mouse lower first molar, and to explore the correlation between its expression and the activity of osteoclasts. Methods: Mouse mandibles were dissected from mice at day 1.5 to 14.5 after birth. They were then serially sectioned and stained respectively using hemotoxylin, tartrate-resistant acid phosphatase (TRAP) staining, and immunohistochemical staining. SPSS 25.0 software package was used for data analysis. Results: During the eruption of mouse lower first molar, the thickness of the crown alveolar bone gradually decreased, so did the number of osteoclasts and the expression of HIF-1α. Conclusions: During the eruption of mouse lower first molar, the less expression of HIF-1α, the fewer osteoclasts there were. HIF-1α may be involved in the eruption of mouse lower first molar by regulating the activity of osteoclasts.
Databáze:	MEDLINE
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