Cytokines and pregnancy: Potential regulation by histone deacetylases.

Autor: Munro SK; Liggins Institute, The University of Auckland, Auckland, New Zealand., Balakrishnan B; Liggins Institute, The University of Auckland, Auckland, New Zealand., Lissaman AC; Liggins Institute, The University of Auckland, Auckland, New Zealand., Gujral P; Liggins Institute, The University of Auckland, Auckland, New Zealand., Ponnampalam AP; Liggins Institute, The University of Auckland, Auckland, New Zealand.; Department of Physiology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.
Jazyk: angličtina
Zdroj: Molecular reproduction and development [Mol Reprod Dev] 2021 May; Vol. 88 (5), pp. 321-337. Date of Electronic Publication: 2021 Apr 26.
DOI: 10.1002/mrd.23430
Abstrakt: Cytokines are important regulators of pregnancy and parturition. Aberrant expression of proinflammatory cytokines during pregnancy contributes towards preterm labor, pre-eclampsia, and gestational diabetes mellitus. The regulation of cytokine expression in human cells is highly complex, involving interactions between environment, transcription factors, and feedback mechanisms. Recent developments in epigenetic research have made tremendous advancements in exploring histone modifications as a key epigenetic regulator of cytokine expression and the effect of their signaling molecules on various organ systems in the human body. Histone acetylation and subsequent deacetylation by histone deacetylases (HDACs) are major epigenetic regulators of protein expression in the human body. The expression of various proinflammatory cytokines, their role in normal and abnormal pregnancy, and their epigenetic regulation via HDACs will be discussed in this review.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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