Protective effects of whey protein concentrate admixtured of curcumin on metabolic control, inflammation and oxidative stress in Wistar rats submitted to exhaustive exercise.

Autor:	Rosignoli da Conceição A; Laboratory of Vitamin Analysis, Department of Nutrition and Health, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Dias KA; Laboratory of Vitamin Analysis, Department of Nutrition and Health, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Michelin Santana Pereira S; Laboratory of Vitamin Analysis, Department of Nutrition and Health, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Saraiva LC; Laboratory of Vitamin Analysis, Department of Nutrition and Health, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Alves Oliveira L; Laboratory of Vitamin Analysis, Department of Nutrition and Health, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Gomes de Souza EC; Laboratory of New Food Development, Department of Nutrition and Health, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Vilela Gonçalves R; Laboratory of Experimental Pathology, Department of Animal Biology, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Pinto da Matta SL; Laboratory of Structural Biology, Department of General Biology, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Natali AJ; Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Martino HSD; Laboratory of Experimental Nutrition, Department of Nutrition and Health, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil., Mattos Della Lucia C; Laboratory of Vitamin Analysis, Department of Nutrition and Health, Federal University of Vicosa, Av. Peter Henry Rolfs, s/n - Campus Universitário, ViçosaMG 36570-900, Brasil.
Jazyk:	angličtina
Zdroj:	The British journal of nutrition [Br J Nutr] 2022 Feb 28; Vol. 127 (4), pp. 526-539. Date of Electronic Publication: 2021 Apr 27.
DOI:	10.1017/S0007114521001355
Abstrakt:	This work aimed to evaluate the effects of whey protein concentrate (WPC) admixtured of curcumin on metabolic control, inflammation and oxidative stress in Wistar rats submitted to exhaustive exercise. A total of forty-eight male rats were divided into six experimental groups (n 8): standard diet group (AIN-93M), standard diet submitted to exhaustion test group (AIN-93M ET), WPC admixtured of curcumin group (WPC + CCM), WPC + CCM submitted to exhaustion test group (WPC + CCM ET), CCM group and CCM subjected to exhaustion test group (CCM ET). The swimming exhaustion test was performed after 4 weeks of experiment. The consumption of WPC + CCM as well as isolated CCM did not alter the biometric measurements, the animals' food consumption and the hepatic and kidney function, as well as the protein balance of the animals (P > 0·05), but reduced the glycaemia and the gene expression of TNF-α and IL-6 and increased the expression of IL-10 (P < 0·05). The animals that were submitted to the exhaustion test (AIN-93M ET) showed higher aspartate aminotransferase values when compared to the animals that did not perform the exercise (AIN-93 M) (P < 0·05). WPC + CCM reduced the concentration of nitric oxide, carbonylated protein and increased the concentration of catalase (P < 0·05). Both (WPC + CCM and CCM) were able to increase the concentrations of superoxide dismutase (P < 0·05). We concluded that the WPC admixtured of CCM represents a strategy capable of decreasing blood glucose and oxidative and inflammatory damage caused by exhaustive physical exercise in swimming.
Databáze:	MEDLINE
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