Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome.

Autor: Laden BF; Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC., Bresee C; Department of Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA., De Hoedt A; Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC., Dallas KB; Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA., Scharfenberg A; Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC., Saxena R; Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC., Senechal JF; Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC., Barbour KE; National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA., Kim J; Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA., Freedland SJ; Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC; Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA., Anger JT; Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: Jennifer.Anger@cshs.org.
Jazyk: angličtina
Zdroj: Urology [Urology] 2021 Oct; Vol. 156, pp. 37-43. Date of Electronic Publication: 2021 Apr 23.
DOI: 10.1016/j.urology.2021.04.015
Abstrakt: Objective: To examine the prevalence of comorbid conditions in a nationwide population of men and women with IC/BPS utilizing a more heterogeneous sample than most studies to date.
Methods: Using the Veterans Affairs Informatics and Computing Infrastructure, we identified random samples of male and female patients with and without an ICD-9/ICD-10 diagnosis of IC/BPS. Presence of comorbidities (NUAS [chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, migraines], back pain, diabetes, and smoking) and psychosocial factors (alcohol abuse, post-traumatic stress disorder, sexual trauma, and history of depression) were determined using ICD-9 and ICD-10 codes. Associations between these variables and IC/BPS status were evaluated while adjusting for the potential confounding impact of race/ethnicity, age, and gender.
Results: Data was analyzed from 872 IC/BPS patients (355 [41%] men, 517 [59%] women) and 558 non-IC/BPS patients (291 [52%] men, 267 [48%] women). IC/BPS patients were more likely than non-IC/BPS patients to have a greater number of comorbidities (2.72+/-1.77 vs 1.73+/-1.30, P < 0.001), experience one or more NUAS (chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and migraines) (45% [388/872] vs. 18% [101/558]; P < 0.001) and had a higher prevalence of at least one psychosocial factor (61% [529/872] v. 46% [256/558]; P < 0.001). Differences in the frequencies of comorbidities between patients with and without IC/BPS were more pronounced in female patients.
Conclusion: These findings validate the findings of previous comorbidity studies of IC/BPS in a more diverse population.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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