Androgen receptor gene microsatellite polymorphism is associated with muscle mass and strength in bodybuilders and power athlete status.

Autor: Guilherme JPLF; Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil., V Shikhova Y; Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St Petersburg, Russia., R Dondukovskaya R; Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St Petersburg, Russia.; Weider College of Fitness and Bodybuilding, St Petersburg, Russia., A Topanova A; Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St Petersburg, Russia.; Institute of Medical Education, Almazov National Medical Research Centre, St Petersburg, Russia., A Semenova E; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.; Sport Technology Research Center, Volga Region State University of Physical Culture, Sport and Tourism, Kazan, Russia., V Astratenkova I; Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St Petersburg, Russia.; Department of Physiology, St Petersburg State University, St Petersburg, Russia., Ahmetov II; Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St Petersburg, Russia.; Department of Physical Education, Plekhanov Russian University of Economics, Moscow, Russia.; Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, Russia.; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Jazyk: angličtina
Zdroj: Annals of human biology [Ann Hum Biol] 2021 Mar; Vol. 48 (2), pp. 142-149. Date of Electronic Publication: 2021 May 10.
DOI: 10.1080/03014460.2021.1919204
Abstrakt: Background: The androgen receptor ( AR ) gene contains a polymorphic trinucleotide (CAG) microsatellite repeat sequence (short or long alleles) that has been associated with fat-free mass in untrained men, which needs to be replicated in athletic cohorts.
Aim: The purpose of this study was to explore the AR (CAG) n polymorphism in trained individuals.
Subjects and Methods: A total of 61 professional bodybuilders (40 males, 21 females), 73 elite male sprinters and weightlifters and 186 male controls were enrolled in this study. The influence of the AR (CAG) n polymorphism on muscle mass and strength was assessed in bodybuilders, while the frequencies of AR (CAG) n alleles were compared between power athletes and non-athletes.
Results: The polymorphism was associated with anthropometric and strength measurements in bodybuilders of both genders. Those with ≥21 CAG repeats (i.e. carriers of long alleles) exhibited greater ( p  < 0.05) body mass index, absolute muscle mass, arm/thigh circumference and upper/lower limb strength compared to those with <21 CAG repeats. Furthermore, carriers of ≥21 CAG repeats were more frequent among power athletes compared to controls ( p  = 0.0076).
Conclusions: Long alleles of the AR (CAG) n polymorphism were associated with greater muscle mass and strength in bodybuilders, and power athlete status.
Databáze: MEDLINE
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