Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder.

Autor:	Bountress KE; Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University (VCU), Richmond, VA, United States., Vladimirov V; Department of Psychiatry and Behavioral Sciences, College of Medicine Texas A&M University, Richmond, VA, United States.; Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, United States., McMichael G; Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University (VCU), Richmond, VA, United States., Taylor ZN; Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University (VCU), Richmond, VA, United States., Hardiman G; Institute for Global Food Security, Queens University Belfast, Belfast, United Kingdom., Chung D; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States., Adams ZW; Department of Psychiatry, Indiana University of Medicine, Indianapolis, IN, United States., Danielson CK; National Crime Victim Research and Treatment Center, Medical University of South Carolina, Charleston, SC, United States.; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States., Amstadter AB; Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University (VCU), Richmond, VA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2021 Apr 08; Vol. 12, pp. 581093. Date of Electronic Publication: 2021 Apr 08 (Print Publication: 2021).
DOI:	10.3389/fpsyt.2021.581093
Abstrakt:	Background: The purpose of this study was to identify gene expression differences associated with post-traumatic stress disorder (PTSD) and trauma exposure (TE) in a three-group study design comprised of those with and without trauma exposure and PTSD. Methods: We conducted gene expression and gene network analyses in a sample ( n = 45) composed of female subjects of European Ancestry (EA) with PTSD, TE without PTSD, and controls. Results: We identified 283 genes differentially expressed between PTSD-TE groups. In an independent sample of Veterans ( n = 78) a small minority of these genes were also differentially expressed. We identified 7 gene network modules significantly associated with PTSD and TE (Bonferroni corrected p ≤ 0.05), which at a false discovery rate (FDR) of q ≤ 0.2, were significantly enriched for biological pathways involved in focal adhesion, neuroactive ligand receptor interaction, and immune related processes among others. Conclusions: This study uses gene network analyses to identify significant gene modules associated with PTSD, TE, and controls. On an individual gene level, we identified a large number of differentially expressed genes between PTSD-TE groups, a minority of which were also differentially expressed in the independent sample. We also demonstrate a lack of network module preservation between PTSD and TE, suggesting that the molecular signature of PTSD and trauma are likely independent of each other. Our results provide a basis for the identification of likely disease pathways and biomarkers involved in the etiology of PTSD. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Bountress, Vladimirov, McMichael, Taylor, Hardiman, Chung, Adams, Danielson and Amstadter.)
Databáze:	MEDLINE
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