COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin.

Autor: Mansoor T; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA., Alsarah AA; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA., Mousavi H; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA., Khader Eliyas J; University of New Mexico, Department of Neurosurgery, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA., Girotra T; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA., Hussein O; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA. Electronic address: ohussein@salud.unm.edu.
Jazyk: angličtina
Zdroj: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2021 Jul; Vol. 30 (7), pp. 105822. Date of Electronic Publication: 2021 Apr 12.
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105822
Abstrakt: There have been limited cases linking SARS-CoV-2 infection with the development of reversible cerebral vasoconstriction syndrome (RCVS). We hereby report a rare case of RCVS in the setting of mild SARS-CoV-2 respiratory infection successfully treated with nimodipine and aspirin. SARS-CoV-2 attacks the ACE2-receptors, which are expressed in various body organs including the lungs, kidneys, and blood vessels. Vasoconstriction can result from down-regulation of the ACE2-receptors that can lead to sympathetic hypertonia of the cerebral blood vessel walls and/or over-activation of the renin-angiotensin axis.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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