Sensitive and selective detections of mustard gas and its analogues by 4-mercaptocoumarins as fluorescent chemosensors in both solutions and gas phase.

Autor: Xue MJ; Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China., Wei XZ; Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China., Feng W; Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China., Xing ZF; The Laboratory of Analytical Chemistry, Research Institute of Chemical Defence, Beijing 102205, PR China., Liu SL; The Laboratory of Analytical Chemistry, Research Institute of Chemical Defence, Beijing 102205, PR China., Song QH; Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China. Electronic address: qhsong@ustc.edu.cn.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2021 Aug 15; Vol. 416, pp. 125789. Date of Electronic Publication: 2021 Apr 06.
DOI: 10.1016/j.jhazmat.2021.125789
Abstrakt: Mustard gas has been used as a chemical warfare agent for a century, and is the most likely chemical weapon used in wars or by terrorists. Thus, it is important to develop a facile, rapid and highly selective method for the detection of mustard gas. In this paper, two fluorescent probe molecules, 4-mercaptocoumarins, have been developed for rapid and sensitive detections of SM and its analogues (CEES and NH1) in both solutions and gas phase. The sensing reaction is a nucleophilic addition at three-membered hetercyclic sulfonium/ammonium formed from SM, CEES/NH1 in ethanol. Two fluorescent probes (4-mercaptocoumarins, ArSH) in ethanol deprotonate to form thiophenol anions (ArS - ) resulting from their low pKa values (3.2-3.4), and the nucleophilic addition of the anion ArS - generates the corresponding thioethers, giving a turn-on fluorescence response. The thiophenol anion can fast sense SM, CEES and NH1 (within 1-4 min) with high sensitivity (~nM level) at 60 °C, and high selectivity through adding a tertiary amine, and two probes exhibit excellent chemical and photostability in detection systems. Furthermore, a facile test strip with the sensor was fabricated for the detection of CEES vapor with rapid response (3 min), high sensitivity (9 ppb) and high selectivity.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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