40-Hz auditory stimulation for intracranial interictal activity: A pilot study.

Autor: Quon RJ; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Leslie GA; Department of Music, Georgia Institute of Technology, Atlanta, GA, USA., Camp EJ; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Meisenhelter S; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Steimel SA; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Song Y; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Ettinger AB; United Diagnostics, New Hyde Park, NY, USA., Bujarski KA; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Casey MA; Department of Music at Dartmouth College, Hanover, NH, USA.; Department of Computer Science at Dartmouth College, Hanover, NH, USA., Jobst BC; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Jazyk: angličtina
Zdroj: Acta neurologica Scandinavica [Acta Neurol Scand] 2021 Aug; Vol. 144 (2), pp. 192-201. Date of Electronic Publication: 2021 Apr 24.
DOI: 10.1111/ane.13437
Abstrakt: Objectives: To study the effects of auditory stimuli on interictal epileptiform discharge (IED) rates evident with intracranial monitoring.
Materials and Methods: Eight subjects undergoing intracranial EEG monitoring for refractory epilepsy participated in this study. Auditory stimuli consisted of a 40-Hz tone, a 440-Hz tone modulated by a 40-Hz sinusoid, Mozart's Sonata for Two Pianos in D Major (K448), and K448 modulated by a 40-Hz sinusoid (modK448). Subjects were stratified into high- and low-IED rate groups defined by baseline IED rates. Subject-level analyses identified individual responses to auditory stimuli, discerned specific brain regions with significant reductions in IED rates, and examined the influence auditory stimuli had on whole-brain sigma power (12-16 Hz).
Results: All subjects in the high baseline IED group had a significant 35.25% average reduction in IEDs during the 40-Hz tone; subject-level reductions localized to mesial and lateral temporal regions. Exposure to Mozart K448 showed significant yet less homogeneous responses. A post hoc analysis demonstrated two of the four subjects with positive IED responses had increased whole-brain power at the sigma frequency band during 40-Hz stimulation.
Conclusions: Our study is the first to evaluate the relationship between 40-Hz auditory stimulation and IED rates in refractory epilepsy. We reveal that 40-Hz auditory stimuli may be a noninvasive adjunctive intervention to reduce IED burden. Our pilot study supports the future examination of 40-Hz auditory stimuli in a larger population of subjects with high baseline IED rates.
(© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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