Modeling of Acute Pulmonary Arterial Hypertension in Pigs Using a Stable Thromboxane A 2 Analogue (U46619): Dose Adjustment and Assessment of Hemodynamic Reactions.

Autor: Goncharova NS; Non-Coronary Heart Diseases Research Department, St. Petersburg, Russia. ns.goncharova@gmail.com., Andreeva EM; Non-Coronary Heart Diseases Research Department, St. Petersburg, Russia., Vakhrushev AD; Neuromodulation Research Laboratory, St. Petersburg, Russia., Leandro HIC; Neuromodulation Research Laboratory, St. Petersburg, Russia., Murashova LA; Center for Preclinical and Translational Research, St. Petersburg, Russia., Voronin SE; Center for Preclinical and Translational Research, St. Petersburg, Russia., Korobchenko LE; Neuromodulation Research Laboratory, St. Petersburg, Russia., Mitrofanova LB; Research Laboratory of Pathomorphology, V. A. Almazov National Medical Research Centre, Ministry of Health the Russian Federation, St. Petersburg, Russia., Skorik YA; Center for Preclinical and Translational Research, St. Petersburg, Russia., Galagudza MM; Center for Preclinical and Translational Research, St. Petersburg, Russia., Moiseeva OM; Non-Coronary Heart Diseases Research Department, St. Petersburg, Russia., Mikhaylov EN; Neuromodulation Research Laboratory, St. Petersburg, Russia.; Arrhythmia Research Department, St. Petersburg, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Apr; Vol. 170 (6), pp. 729-733. Date of Electronic Publication: 2021 Apr 24.
DOI: 10.1007/s10517-021-05142-2
Abstrakt: U46619, a synthetic analogue of thromboxane A2 was used for modeling acute stable and reversible pulmonary arterial hypertension. Administration of U46619 in high doses led to vascular collapse and inhibition of cardiac function. The doses of U46619 were empirically selected that allow attaining the target level of pulmonary hypertension without systemic hemodynamic disturbances. The possibility of attaining the target level of pulmonary hypertension and reversibility of changes after termination of U46619 infusion make this model attractive for evaluation of the efficiency of different therapeutic methods of treatment of pulmonary hypertension in large animals.
Databáze: MEDLINE
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