Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: A Danish Nationwide Cohort Study.

Autor:	Broccia M; Department of Obstetrics and Gynaecology, Aalborg University Hospital, Reberbansgade, Aalborg, Denmark.; Department of Cardiology, Nordsjællands Hospital, Dyrehavevej, Hillerød, Denmark., de Knegt VE; Department of Pediatrics, Hvidovre Hospital, Kettegård alle, Hvidovre, Denmark., Mills EHA; Department of Cardiology, Aalborg University Hospital, Hobrovej, Aalborg, Denmark., Møller AL; Department of Cardiology, Nordsjællands Hospital, Dyrehavevej, Hillerød, Denmark., Gnesin F; Department of Cardiology, Nordsjællands Hospital, Dyrehavevej, Hillerød, Denmark., Fischer TK; Department of Clinical Research, Nordsjællands Hospital, Dyrehavevej, Hillerød, Denmark., Zylyftari N; Department of Cardiology, Nordsjællands Hospital, Dyrehavevej, Hillerød, Denmark., Blomberg SN; Emergency Medical Services, University of Copenhagen, Region Hovedstaden (Capital Region of Denmark)., Andersen MP; Department of Cardiology, Nordsjællands Hospital, Dyrehavevej, Hillerød, Denmark., Schou M; Department of Cardiology, Herlev Gentofte Hospital, Hospitalsvej, Hellerup, Denmark., Fosbøl E; Department of Cardiology, Rigshospitalet, Blegdamsvej, København Ø, Denmark., Kragholm K; Department of Cardiology, Herlev Gentofte Hospital, Hospitalsvej, Hellerup, Denmark.; Unit of Clinical Biostatistics and Epidemiology, Aalborg University Hospital, Reberbansgade, Aalborg, Denmark., Christensen HC; Danish Clinical Quality Program (RKKP), National Clinical Registries, Frederiksberg Hospital, Denmark., Polcwiartek LB; Department of Pediatrics, Aalborg University Hospital, Reberbansgade, Aalborg, Denmark., Phelps M; The Danish Heart Foundation, Copenhagen, Denmark., Køber L; Unit of Clinical Biostatistics and Epidemiology, Aalborg University Hospital, Reberbansgade, Aalborg, Denmark., Torp-Pedersen C; Department of Cardiology, Nordsjællands Hospital, Dyrehavevej, Hillerød, Denmark.; Department of Cardiology, Aalborg University Hospital, Hobrovej, Aalborg, Denmark.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2022 Jan 07; Vol. 74 (1), pp. 1-7.
DOI:	10.1093/cid/ciab340
Abstrakt:	Background: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity. Methods: We performed a Danish, nationwide, register-based, cohort study including laboratory-confirmed SARS-CoV-2-infected individuals from 22 February 2020 to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having 1 individual test positive for SARS-CoV-2 within the household. Cox proportional hazards models were used to estimate the association between "critical COVID-19" within and between households with and without secondary cases. Results: From 15 063 multiperson households, 19 773 SARS-CoV-2-positive individuals were included; 11 632 were categorized as index cases without any secondary household cases; 3431 as index cases with secondary cases, that is, 22.8% of multiperson households; and 4710 as secondary cases. Critical COVID-19 occurred in 2.9% of index cases living with no secondary cases, 4.9% of index cases with secondary cases, and 1.3% of secondary cases. The adjusted hazard ratio for critical COVID-19 among index cases vs secondary cases within the same household was 2.50 (95% confidence interval [CI], 1.88-3.34), 2.27 (95% CI, 1.77-2.93) for index cases in households with no secondary cases vs secondary cases, and 1.1 (95% CI, .93-1.30) for index cases with secondary cases vs index cases without secondary cases. Conclusions: We found no increased hazard ratio of critical COVID-19 among household members of infected SARS-CoV-2 index cases. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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