| Autor: |
Pirch S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria., Müller F; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria., Iofinova E; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Pazmandi J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria., Hütter CVR; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria., Chiettini M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria., Sin C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria., Boztug K; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Podkosova I; Institute of Visual Computing and Human-Centered Technology, TU Wien, Vienna, Austria., Kaufmann H; Institute of Visual Computing and Human-Centered Technology, TU Wien, Vienna, Austria., Menche J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. joerg.menche@univie.ac.at.; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria. joerg.menche@univie.ac.at.; Faculty of Mathematics, University of Vienna, Vienna, Austria. joerg.menche@univie.ac.at. |
| Abstrakt: |
Networks provide a powerful representation of interacting components within complex systems, making them ideal for visually and analytically exploring big data. However, the size and complexity of many networks render static visualizations on typically-sized paper or screens impractical, resulting in proverbial 'hairballs'. Here, we introduce a Virtual Reality (VR) platform that overcomes these limitations by facilitating the thorough visual, and interactive, exploration of large networks. Our platform allows maximal customization and extendibility, through the import of custom code for data analysis, integration of external databases, and design of arbitrary user interface elements, among other features. As a proof of concept, we show how our platform can be used to interactively explore genome-scale molecular networks to identify genes associated with rare diseases and understand how they might contribute to disease development. Our platform represents a general purpose, VR-based data exploration platform for large and diverse data types by providing an interface that facilitates the interaction between human intuition and state-of-the-art analysis methods. |
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