Comparative genomic analysis of sifakas ( Propithecus ) reveals selection for folivory and high heterozygosity despite endangered status.

Autor:	Guevara EE; Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA. eg197@duke.edu jr13@bcm.edu.; Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC 20052, USA., Webster TH; Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USA., Lawler RR; Department of Sociology and Anthropology, James Madison University, Harrisonburg, VA 22807, USA., Bradley BJ; Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC 20052, USA., Greene LK; Duke Lemur Center, Duke University, Durham, NC 27705, USA.; Department of Biology, Duke University, Durham, NC 27708-0338, USA., Ranaivonasy J; Département Agroécologie, Biodiversité et Changement Climatique, ESSA, University of Antananarivo, Antananarivo, Madagascar., Ratsirarson J; Département Agroécologie, Biodiversité et Changement Climatique, ESSA, University of Antananarivo, Antananarivo, Madagascar., Harris RA; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Liu Y; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Murali S; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Raveendran M; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Hughes DST; M2GEN, P.O. Box 5519, Hudson, FL 34667, USA., Muzny DM; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Yoder AD; Department of Biology, Duke University, Durham, NC 27708-0338, USA., Worley KC; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Rogers J; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. eg197@duke.edu jr13@bcm.edu.; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2021 Apr 23; Vol. 7 (17). Date of Electronic Publication: 2021 Apr 23 (Print Publication: 2021).
DOI:	10.1126/sciadv.abd2274
Abstrakt:	Sifakas (genus Propithecus ) are critically endangered, large-bodied diurnal lemurs that eat leaf-based diets and show corresponding anatomical and microbial adaptations to folivory. We report on the genome assembly of Coquerel's sifaka ( P. coquereli ) and the resequenced genomes of Verreaux's ( P. verreauxi ), the golden-crowned ( P. tattersalli ), and the diademed ( P. diadema ) sifakas. We find high heterozygosity in all sifakas compared with other primates and endangered mammals. Demographic reconstructions nevertheless suggest declines in effective population size beginning before human arrival on Madagascar. Comparative genomic analyses indicate pervasive accelerated evolution in the ancestral sifaka lineage affecting genes in several complementary pathways relevant to folivory, including nutrient absorption and xenobiotic and fatty acid metabolism. Sifakas show convergent evolution at the level of the pathway, gene family, gene, and amino acid substitution with other folivores. Although sifakas have relatively generalized diets, the physiological challenges of habitual folivory likely led to strong selection. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
Databáze:	MEDLINE
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