The influence of rs53576 polymorphism in the oxytocin receptor ( OXTR ) gene on empathy in healthy adults by subtype and ethnicity: a systematic review and meta-analysis.

Autor:	Chander RJ; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia., Mather KA; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.; Neuroscience Research Australia (NeuRA), Sydney, NSW 2031, Australia., Cleary R; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia., Grainger SA; School of Psychology, The University of Queensland, St Lucia, QLD, Australia., Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia., Numbers K; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia., Kochan NA; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia., Armstrong NJ; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.; Discipline of Mathematics and Statistics, Curtin University, Perth, WA 6102, Australia., Brodaty H; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.; Dementia Centre for Research Collaboration (DCRC), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia., Henry JD; School of Psychology, The University of Queensland, St Lucia, QLD, Australia., Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia.
Jazyk:	angličtina
Zdroj:	Reviews in the neurosciences [Rev Neurosci] 2021 Apr 26; Vol. 33 (1), pp. 43-57. Date of Electronic Publication: 2021 Apr 26 (Print Publication: 2022).
DOI:	10.1515/revneuro-2021-0038
Abstrakt:	Empathy is essential for navigating complex social environments. Prior work has shown associations between rs53576, a single nucleotide polymorphism (SNP) located in the oxytocin receptor gene ( OXTR ), and generalized empathy. We undertook a systematic review and meta-analysis to assess the effects of rs53576 on subdomains of empathy, specifically cognitive empathy (CE) and affective empathy (AE), in healthy adults. Twenty cohorts of 8933 participants aged 18-98 were identified, including data from the Sydney Memory and Ageing Study, a cohort of older community adults. Meta-analyses found G homozygotes had greater generalized empathic abilities only in young to middle-aged adults. While meta-analyses of empathy subdomains yielded no significant overall effects, there were differential effects based on ethnicity. G homozygotes were associated with greater CE abilities in Asian cohorts (standardized mean difference; SMD: 0.09 [2.8·10 -3 -0.18]), and greater AE performance in European cohorts [SMD: 0.12 (0.04-0.21)]. The current literature highlights a need for further work that distinguishes between genetic and ethnocultural effects and explores effects of advanced age on this relationship. (© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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