Changes in Sedation Practices in Association with Delirium Screening in Infants After Cardiopulmonary Bypass.

Autor: Chomat MR; Division of Pediatric Cardiology, Washington University in St. Louis, St. Louis, USA.; Division of Pediatric Critical Care Medicine, Washington University in St. Louis, St. Louis, USA., Said AS; Division of Pediatric Critical Care Medicine, Washington University in St. Louis, St. Louis, USA., Mann JL; St. Louis Children's Hospital, Washington University in St. Louis, St. Louis, USA., Wallendorf M; Division of Biostatistics, Washington University in St. Louis, St. Louis, USA., Bickhaus A; St. Louis Children's Hospital, Washington University in St. Louis, St. Louis, USA., Figueroa M; Division of Pediatric Cardiology, Washington University in St. Louis, St. Louis, USA. figueroamaytei@wustl.edu.; Division of Pediatric Critical Care Medicine, Washington University in St. Louis, St. Louis, USA. figueroamaytei@wustl.edu.; Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8116, St. Louis, MO, 63110-1093, USA. figueroamaytei@wustl.edu.
Jazyk: angličtina
Zdroj: Pediatric cardiology [Pediatr Cardiol] 2021 Aug; Vol. 42 (6), pp. 1334-1340. Date of Electronic Publication: 2021 Apr 23.
DOI: 10.1007/s00246-021-02616-y
Abstrakt: Sedation in the cardiac intensive care unit (CICU) is necessary to keep critically ill infants safe and comfortable. However, long-term use of sedatives may be associated with adverse neurodevelopmental outcomes. We aimed to examine sedation practices in the CICU after the implementation of the Cornell Assessment of Pediatric Delirium (CAPD). We hypothesize the use of the CAPD would be associated with a decrease in sedative weans at CICU discharge. This is a single institution, retrospective cohort study. The study inclusion criteria were term infants, birthweight > 2.5 kg, cardiopulmonary bypass (CPB), and mechanical ventilation (MV) on postoperative day zero. During the study period, 50 and 35 patients respectively, met criteria pre- and post-implementation of CAPD screening. Our results showed a statistically significant increase in the incidence of sedative habituation wean at CICU discharge after CAPD implementation (24% vs. 45.7%, p = 0.036). There was a statistically significant increase in exposure to opiate (56% vs. 88.6%, p = 0.001) and dexmedetomidine infusions (52% vs 80%, p = 0.008), increased likelihood of clonidine use at CICU discharge (OR 9.25, CI 2.39-35.84), and increase in the duration of intravenous sedative infusions (8.1 days vs. 5.1 days, p = 0.04) No statistical difference was found in exposure to fentanyl (42% vs. 58.8%, p = 0.13) or midazolam infusions (22% vs. 25.7%, p = 0.691); and there was no change in benzodiazepine or opiate use at CICU discharge or dosage. The prevalence of delirium in the CAPD cohort was 92%. CAPD implementation in the CICU was associated with changes in sedation practices, specifically an increase in the use of dexmedetomidine, which possibly explains the increased clonidine weans at CICU discharge. This is the first report of the association between CAPD monitoring and changes in sedative practices. Multi-center prospective studies are recommended to evaluate sedative practices, delirium, and its effects on neurodevelopment.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: