Disparities in Cardiovascular Disease Risk Among Hispanic Breast Cancer Survivors in a Population-Based Cohort.

Autor: Hu Q; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; Huntsman Cancer Institute, Salt Lake City, UT, USA., Chang CP; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; Huntsman Cancer Institute, Salt Lake City, UT, USA., Rowe K; Intermountain Healthcare, Salt Lake City, UT, USA., Snyder J; Intermountain Healthcare, Salt Lake City, UT, USA., Deshmukh V; University of Utah Health Sciences Center, Salt Lake City, UT, USA., Newman M; University of Utah Health Sciences Center, Salt Lake City, UT, USA., Fraser A; Pedigree and Population Resource, Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT, USA., Smith K; Pedigree and Population Resource, Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT, USA., Gren LH; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Porucznik C; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Stanford JB; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Gaffney D; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Department of Radiation Oncology, University of Utah, Salt Lake City, UT, USA., Henry NL; Division of Hematology/Oncology, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Lopez I; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Hashibe M; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Utah Cancer Registry, Salt Lake City, UT, USA.
Jazyk: angličtina
Zdroj: JNCI cancer spectrum [JNCI Cancer Spectr] 2021 Feb 15; Vol. 5 (2). Date of Electronic Publication: 2021 Feb 15 (Print Publication: 2021).
DOI: 10.1093/jncics/pkab016
Abstrakt: Background: Breast cancer is the leading cause of cancer death among Hispanic women. The aim of our study was to estimate cardiovascular disease (CVD) risk among Hispanic and non-Hispanic White (NHW) breast cancer survivors compared with their respective general population cohorts.
Methods: Cohorts of 17 469 breast cancer survivors (1774 Hispanic and 15 695 NHW) in the Utah Cancer Registry diagnosed between 1997 and 2016, and 65 866 women (6209 Hispanic and 59 657 NHW) from the general population in the Utah Population Database were identified. Cox proportional hazards models were used to estimate hazard ratios (HRs) for CVD.
Results: The risk of diseases of the circulatory system was higher in Hispanic than NHW breast cancer survivors 1-5 years after cancer diagnosis, in comparison with their respective general population cohorts (HR Hispanic = 1.94, 99% confidence interval [CI] = 1.49 to 2.53; H NHW = 1.38, 99% CI = 1.33 to 1.43; 2-sided P heterogeneity = .01, respectively). Increased risks were observed for both Hispanic and NHW breast cancer survivors for diseases of the heart and the veins and lymphatics, compared with the general population cohorts. More than 5 years after cancer diagnosis, elevated risk of diseases of the veins and lymphatics persisted in both ethnicities. The CVD risk due to chemotherapy and hormone therapy was higher in Hispanic than NHW breast cancer survivors but did not differ for distant stage, higher baseline comorbidities, or baseline smoking.
Conclusions: We observed a risk difference for diseases of the circulatory system between Hispanic and NHW breast cancer survivors compared with their respective general population cohorts but only within the first 5 years of cancer diagnosis.
(© The Author(s) 2021. Published by Oxford University Press.)
Databáze: MEDLINE