Patterns of aggressiveness: risk of progression to invasive breast cancer by mammographic features of calcifications in screen-detected ductal carcinoma in situ.

Autor:	Lilleborge M; Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway., Falk RS; Oslo Centre for Biostatistics & Epidemiology, Oslo University Hospital, Oslo, Norway., Hovda T; Department of Radiology, Vestre Viken Hospital, Drammen, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Holmen MM; Department of Radiology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway., Ursin G; Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway.; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.; Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA., Hofvind S; Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway.; Department of Life Sciences and Health, Oslo Metropolitan University, Oslo Norway *The first author, Marie Lilleborge, is currently affiliated with the 'Norwegian Computing Center, Oslo, Norway'.
Jazyk:	angličtina
Zdroj:	Acta radiologica (Stockholm, Sweden : 1987) [Acta Radiol] 2022 May; Vol. 63 (5), pp. 586-595. Date of Electronic Publication: 2021 Apr 22.
DOI:	10.1177/02841851211006319
Abstrakt:	Background: Mammographic features of calcifications on mammograms showing invasive breast cancer are associated with survival. Less is known about mammographic features and progression to invasive breast cancer among women treated for ductal carcinoma in situ (DCIS). Purpose: To investigate mammographic features of calcifications in screen-detected DCIS in women who later did and did not get diagnosed with invasive breast cancer. Material and Methods: This registry-based nested case-control study analyzed data from women with screen-detected DCIS in BreastScreen Norway, 1995-2016. Within this cohort of women with DCIS, those who were later diagnosed with invasive breast cancer (cases) were matched (1:2) to women who were not diagnosed with invasive breast cancer (controls) after their DCIS and by the end of 2016. Information on mammographic features were collected by a national radiological review, where screening mammograms were reviewed locally at each of the 16 breast centers in Norway. We used conditional logistic regression analysis to estimate associations between mammographic features of calcifications in the DCIS mammogram and the risk of subsequent invasive breast cancer. Results: We found a higher risk of invasive breast cancer associated with fine linear branching (casting) morphology (odds ratio 20.0; 95% confidence interval [CI] 2.5-158.9) compared to fine linear or fine pleomorphic morphology. Regional or diffuse distribution showed an odds ratio of 2.8 (95% CI 1.0-8.2) compared to segmental or linear distribution. Conclusion: Mammographic features of calcifications in screen-detected DCIS were of influence on the risk of invasive breast cancer. Unfavorable characteristics of DCIS were fine linear branching morphology, and regional or diffuse distribution.
Databáze:	MEDLINE
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