Position preference of essential genes in prokaryotic operons.

Autor: Liu T; Department of Physics, School of Science, Tianjin University, Tianjin, China., Luo H; Department of Physics, School of Science, Tianjin University, Tianjin, China., Gao F; Department of Physics, School of Science, Tianjin University, Tianjin, China.; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China.; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Apr 22; Vol. 16 (4), pp. e0250380. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0250380
Abstrakt: Essential genes, which form the basis of life activities, are crucial for the survival of organisms. Essential genes tend to be located in operons, but how they are distributed in operons is still unclear for most prokaryotes. In order to clarify the general rule of position preference of essential genes in operons, an index of the average position of genes in an operon was proposed, and the distributions of essential and non-essential genes in operons in 51 bacterial genomes and two archaeal genomes were analyzed based on this new index. Consequently, essential genes were found to preferentially occupy the front positions of the operons, which tend to be expressed at higher levels.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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