| Autor: |
Gschwend PM; Particle Technology Laboratory, Institute of Energy and Process Engineering, Department of Mechanical and Process Engineering, ETH Zürich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland. pratsinis@ethz.ch., Keevend K, Aellen M, Gogos A, Krumeich F, Herrmann IK, Pratsinis SE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of materials chemistry. B [J Mater Chem B] 2021 Apr 07; Vol. 9 (13), pp. 3038-3046. Date of Electronic Publication: 2021 Mar 19. |
| DOI: |
10.1039/d0tb02792h |
| Abstrakt: |
Deep-tissue fluorescence imaging remains a major challenge as there is limited availability of bright biocompatible materials with high photo- and chemical stability. Contrast agents with emission wavelengths above 1000 nm are most favorable for deep tissue imaging, offering deeper penetration and less scattering than those operating at shorter wavelengths. Organic fluorophores suffer from low stability while inorganic nanomaterials (e.g. quantum dots) are based typically on heavy metals raising toxicity concerns. Here, we report scalable flame aerosol synthesis of water-dispersible Ba 3 (VO 4 ) 2 nanoparticles doped with Mn 5+ which exhibit a narrow emission band at 1180 nm upon near-infrared excitation. Their co-synthesis with Bi 2 O 3 results in even higher absorption and ten-fold increased emission intensity. The addition of Bi 2 O 3 also improved both chemical stability and cytocompatibility by an order of magnitude enabling imaging deep within tissue. Taken together, these bright particles offer excellent photo-, chemical and colloidal stability in various media with cytocompatibility to HeLa cells superior to existing commercial contrast agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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