Clinical relevance of 18 F-FDG PET/CT in the postoperative follow-up of patients with history of medullary thyroid cancer.
| Autor: | Saponjski J; Center for Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia., Macut D; Clinic for Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Saranovic DS; Center for Nuclear Medicine, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Radovic B; Center for Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia., Artiko V; Center for Nuclear Medicine, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. |
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| Jazyk: | angličtina |
| Zdroj: | Radiology and oncology [Radiol Oncol] 2020 Nov 22; Vol. 55 (1), pp. 18-25. Date of Electronic Publication: 2020 Nov 22. |
| DOI: | 10.2478/raon-2020-0069 |
| Abstrakt: | Background: The aim of the study was evaluation of 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography with computed tomography (PET/CT) in the detection of active disease in the patients with suspected recurrence of the medullary thyroid carcinoma (MTC). Patients and Methods: 18 F-FDG PET/CT investigation was performed in 67 patients, investigated from 2010 to 2019. _ Follow up was performed from 6 to 116 months after surgery (median 16.5 months, x± SD = 29±28.9 months). Twenty five of 67 patients underwent 99m Tc-dimercaptosuccinic acid ( 99m Tc-DMSA) scintigraphy, 11 underwent somatostatin receptor scintigraphy (SRS) with 99m Tc-HYNIC TOC while 11 123 I-metaiodobenzylguanidine (MIBG) scintigraphy. Results: From 67 patients, 35 (52.2%) had true positive 18 F-FDG PET/CT findings (TP). Average maximal standardized uptake value (SUVmax) for all TP lesions was 5.01+3.6. In 25 (37.3%) patients findings were true negative (TN). Four (6%) patients had false positive (FP) findings while three (4.5%) were false negative (FN). Thus, sensitivity of the 18 F-FDG PET/ CT was 92.11%, specificity 86.21%, positive predictive value 89.74%, negative predictive value 89.29% and accuracy 89.55%. In 27 patients (40%) 18 F-FDG PET/CT finding influenced further management of the patient. Conclusions: 18 F-FDG PET/CT has high accuracy in the detection of metastases/recurrences of MTC in patients after thyroidectomy as well as in evaluation and the appropriate choice of the therapy. (© 2021 Jelena Saponjski, Djuro Macut, Dragana Sobic Saranovic, Branislava Radovic, Vera Artiko, published by Sciendo.) |
| Databáze: | MEDLINE |
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