Cardiovascular Manifestations in Inflammatory Bowel Disease: A Systematic Review of the Pathogenesis and Management of Pericarditis.

Autor:	Patel RS; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Rohit Reddy S; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Llukmani A; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Hashim A; Behavioral Neurosciences and Psychology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Haddad DR; Plastic and Reconstructive Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Patel DS; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Ahmad F; Emergency Department, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Gordon DK; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Mar 20; Vol. 13 (3), pp. e14010. Date of Electronic Publication: 2021 Mar 20.
DOI:	10.7759/cureus.14010
Abstrakt:	Inflammatory bowel disease (IBD) is a chronic condition of the bowel that can be further categorized into ulcerative colitis and Crohn's disease. Rarely, this condition can be associated with pericarditis, which can be an extraintestinal manifestation of the disease or drug-induced. This review aims to determine the pathogenesis and management of pericarditis in IBD. In this review, the goal is to elucidate the pathogenesis of pericarditis in IBD and determine if pericarditis is an extraintestinal manifestation of IBD or a complication of current drug therapy used to manage IBD. Additionally, this review intends to explain the first-line management of pericarditis in IBD and explore the role of biologicals in attenuating pericarditis. An electronic search was conducted to identify relevant reports of pericarditis in IBD, and a quality assessment was conducted to identify high-quality articles according to the inclusion criteria. Full-text articles from inception to November 2020 were included, while non-English articles, gray literature, and animal studies were excluded. The majority of studies suggest that pericarditis arises as a complication of drug therapy by 5-aminosalicylic acid derivatives such as sulfasalazine, mesalamine, and balsalazide, and it occurs due to IgE-mediated allergic reactions, direct cardiac toxicity, cell-mediated hypersensitivity reactions, and humoral antibody response to therapy. Drug cessation or the initiation of a corticosteroid regimen seems to be the most effective means of managing pericarditis in IBD due to drug therapy or an extraintestinal manifestation. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Patel et al.)
Databáze:	MEDLINE
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