| Autor: |
Oliveira SGD; Department of Dentistry, Faculty of Sciences of Health, Federal University of Jequitinhonha and Mucuri Valleys., Martos J; Department of Semiology and Clinics, Faculty of Dentistry, Federal University of Pelotas., Carvalho RV; Department of Restorative Dentistry, Graduate Program in Dentistry, Meridional Faculty (IMED)., Pereira CMP; Department de Organic Chemistry, Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Campus Universitário., Lund RG; Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Pelotas., Piva E; Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Pelotas. |
| Jazyk: |
angličtina |
| Zdroj: |
Dental materials journal [Dent Mater J] 2021 Jul 31; Vol. 40 (4), pp. 1055-1062. Date of Electronic Publication: 2021 Apr 22. |
| DOI: |
10.4012/dmj.2020-262 |
| Abstrakt: |
The effect of the addition of nystatin and an alternative antifungal derived from pyrazoles in different commercial denture adhesives on their retentive efficacy, cytotoxicity and antimicrobial activity against Candida albicans was evaluated. Commercial denture adhesives were prepared with the inclusion of nystatin and 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamide (pyrazole) in three concentrations: 23.78 %w/w, 3.02 %w/w, and 0.31 %w/w (0.015 g, 0.0015 g, and 0.00015 g, respectively). The retentive efficacy was tested observing the influence of the medium, type of commercial denture type and the test condition (dipping). The antifungal action through disk diffusion and direct contact tests at 1, 4, 8 and 12 h and cytotoxic activity was evaluated in mouse fibroblasts (NIH/3T3) by the MTT reduction colorimetric assay. The addition of pyrazole and nystatin in commercial denture adhesives did not affect retentive efficacy rates and enhanced antifungal actions against Candida albicans. Results show a possibility of using denture adhesives as a delivery system for commercial antifungals (Nystatin) or pyrazole, with the second concentration (1,560 µg-3.02 %w/w) as the most efficient. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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