Switching Sides: How Endogenous Retroviruses Protect Us from Viral Infections.
| Autor: | Srinivasachar Badarinarayan S; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Germany., Sauter D; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany daniel.sauter@med.uni-tuebingen.de.; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of virology [J Virol] 2021 May 24; Vol. 95 (12). Date of Electronic Publication: 2021 May 24 (Print Publication: 2021). |
| DOI: | 10.1128/JVI.02299-20 |
| Abstrakt: | Long disregarded as junk DNA or genomic dark matter, endogenous retroviruses (ERVs) have turned out to represent important components of the antiviral immune response. These remnants of once-infectious retroviruses not only regulate cellular immune activation, but may even directly target invading viral pathogens. In this Gem, we summarize mechanisms by which retroviral fossils protect us from viral infections. One focus will be on recent advances in the role of ERVs as regulators of antiviral gene expression. (Copyright © 2021 American Society for Microbiology.) |
| Databáze: | MEDLINE |
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