Glucocorticoid exposure predicts survival in female baboons.

Autor:	Campos FA; Department of Anthropology, University of Texas at San Antonio, San Antonio, TX 78249-1644, USA. fernando.campos@utsa.edu.; Department of Biology, Duke University, Durham, NC 27708, USA., Archie EA; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA., Gesquiere LR; Department of Biology, Duke University, Durham, NC 27708, USA., Tung J; Department of Biology, Duke University, Durham, NC 27708, USA.; Population Research Institute, Duke University, Durham, NC 27708, USA.; Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA.; Canadian Institute for Advanced Research, 661 University Ave., Suite 505, Toronto, ON M5G 1M1, Canada., Altmann J; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA., Alberts SC; Department of Biology, Duke University, Durham, NC 27708, USA.; Population Research Institute, Duke University, Durham, NC 27708, USA.; Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2021 Apr 21; Vol. 7 (17). Date of Electronic Publication: 2021 Apr 21 (Print Publication: 2021).
DOI:	10.1126/sciadv.abf6759
Abstrakt:	Are differences in hypothalamic-pituitary-adrenal (HPA) axis activation across the adult life span linked to differences in survival? This question has been the subject of considerable debate. We analyze the link between survival and fecal glucocorticoid (GC) measures in a wild primate population, leveraging an unusually extensive longitudinal dataset of 14,173 GC measurements from 242 adult female baboons over 1634 female years. We document a powerful link between GCs and survival: Females with relatively high current GCs or high lifelong cumulative GCs face an elevated risk of death. A hypothetical female who maintained GCs in the top 90% for her age across adulthood would be expected to lose 5.4 years of life relative to a female who maintained GCs in the bottom 10% for her age. Hence, differences among individuals in HPA axis activity provide valuable prognostic information about disparities in life span. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).)
Databáze:	MEDLINE
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