eNose-TB: A trial study protocol of electronic nose for tuberculosis screening in Indonesia.

Autor: Saktiawati AMI; Faculty of Medicine, Public Health and Nursing, Center for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia., Triyana K; Faculty of Mathematics and Natural Sciences, Department of Physics, Universitas Gadjah Mada, Yogyakarta, Indonesia., Wahyuningtias SD; Faculty of Medicine, Public Health and Nursing, Center for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia., Dwihardiani B; Faculty of Medicine, Public Health and Nursing, Center for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia., Julian T; Faculty of Mathematics and Natural Sciences, Department of Physics, Universitas Gadjah Mada, Yogyakarta, Indonesia., Hidayat SN; Faculty of Mathematics and Natural Sciences, Department of Physics, Universitas Gadjah Mada, Yogyakarta, Indonesia., Ahmad RA; Faculty of Medicine, Public Health and Nursing, Center for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Faculty of Medicine, Public Health and Nursing, Department of Biostatistics, Epidemiology, and Population Health, Universitas Gadjah Mada, Yogyakarta, Indonesia., Probandari A; Faculty of Medicine, Public Health and Nursing, Center for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Faculty of Medicine, Department of Public Health, Universitas Sebelas Maret, Surakarta, Indonesia., Mahendradhata Y; Faculty of Medicine, Public Health and Nursing, Center for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Faculty of Medicine, Public Health and Nursing, Department of Health Policy and Management, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Apr 21; Vol. 16 (4), pp. e0249689. Date of Electronic Publication: 2021 Apr 21 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0249689
Abstrakt: Background: Even though conceptually, Tuberculosis (TB) is almost always curable, it is currently the world's leading infectious killer. Patients with pulmonary TB are the source of transmission. Approximately 23% of the world's population is believed to be latently infected with TB bacteria, and 5-15% of them will progress at any point in time to develop the disease. There was a global diagnostic gap of 2.9 million between notifications of new cases and the estimated number of incident cases, and Indonesia carries the third-highest of this gap. Therefore, screening TB among the community is of great importance to prevent further transmission and infection. The electronic nose for screening TB (eNose-TB) project is initiated in Yogyakarta, Indonesia, to screen TB by breath test with an electronic-nose that is easy-to-use, point-of-care, does not expose patients to radiation, and can be produced at low cost.
Methods/design: The objectives of the two-phase planned project are to: 1) investigate the potential of an eNose-TB as a screening tool in Indonesia, in comparison with screening with clinical symptoms and chest radiology, which are currently used as a standard, and 2) analyze the time and cost of a screening algorithm with eNose-TB to obtain additional case detection. A cross-sectional study will be conducted in the first phase to validate the eNose-TB. The validation phase will involve 395 presumptive TB patients in the Surakarta General Hospital, Central Java. In the second phase, a cross-sectional research will be conducted, involving 1,383 adults and children in the municipality of Yogyakarta and Kulon Progo district of Yogyakarta Province.
Discussion: The findings will provide data concerning the sensitivity and specificity of the eNose-TB as a screening tool for tuberculosis, and the time and cost analysis of a screening algorithm with the eNose.
Trial Registration: NCT04567498; https://clinicaltrials.gov/.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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