Corollary discharge promotes a sustained motor state in a neural circuit for navigation.

Autor:	Ji N; Department of Physics and Center for Brain Science, Harvard University, Cambridge, United States., Venkatachalam V; Department of Physics and Center for Brain Science, Harvard University, Cambridge, United States., Rodgers HD; Department of Physics and Center for Brain Science, Harvard University, Cambridge, United States.; Department of Neurobiology, University of Massachusetts Medical School, Worcester, United States., Hung W; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Departments of Molecular Genetics, and Physiology, University of Toronto, Toronto, Canada., Kawano T; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Departments of Molecular Genetics, and Physiology, University of Toronto, Toronto, Canada., Clark CM; Department of Neurobiology, University of Massachusetts Medical School, Worcester, United States., Lim M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Departments of Molecular Genetics, and Physiology, University of Toronto, Toronto, Canada., Alkema MJ; Department of Neurobiology, University of Massachusetts Medical School, Worcester, United States., Zhen M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Departments of Molecular Genetics, and Physiology, University of Toronto, Toronto, Canada., Samuel AD; Department of Physics and Center for Brain Science, Harvard University, Cambridge, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 Apr 21; Vol. 10. Date of Electronic Publication: 2021 Apr 21.
DOI:	10.7554/eLife.68848
Abstrakt:	Animals exhibit behavioral and neural responses that persist on longer timescales than transient or fluctuating stimulus inputs. Here, we report that Caenorhabditis elegans uses feedback from the motor circuit to a sensory processing interneuron to sustain its motor state during thermotactic navigation. By imaging circuit activity in behaving animals, we show that a principal postsynaptic partner of the AFD thermosensory neuron, the AIY interneuron, encodes both temperature and motor state information. By optogenetic and genetic manipulation of this circuit, we demonstrate that the motor state representation in AIY is a corollary discharge signal. RIM, an interneuron that is connected with premotor interneurons, is required for this corollary discharge. Ablation of RIM eliminates the motor representation in AIY, allows thermosensory representations to reach downstream premotor interneurons, and reduces the animal's ability to sustain forward movements during thermotaxis. We propose that feedback from the motor circuit to the sensory processing circuit underlies a positive feedback mechanism to generate persistent neural activity and sustained behavioral patterns in a sensorimotor transformation. Competing Interests: NJ, VV, HR, WH, TK, CC, ML, MA, MZ, AS No competing interests declared (© 2021, Ji et al.)
Databáze:	MEDLINE
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