Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cells.

Autor: Mishra PK; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Bruiners N; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Ukey R; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Datta P; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Onyuka A; Global Tuberculosis Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Handler D; Global Tuberculosis Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Hussain S; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901., Honnen W; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Singh S; NJMS Flow Cytometry and Immunology Core Laboratory, Rutgers New Jersey Medical School, Newark, NJ 07103., Guerrini V; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Yin Y; Center for Advanced Biotechnology and Medicine, School of Public Health, Rutgers University, Piscataway, NJ 08854., Dewald H; Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103., Choudhary A; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Horton DB; Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901., Barrett ES; Environmental and Occupational Health Sciences Institute, School of Public Health, Rutgers University, Piscataway, NJ 08854.; Department of Biostatistics and Epidemiology, School of Public Health, Rutgers University, Piscataway, NJ 08854., Roy J; Department of Biostatistics and Epidemiology, School of Public Health, Rutgers University, Piscataway, NJ 08854., Weiss SH; Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103., Fitzgerald-Bocarsly P; Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103., Blaser MJ; Center for Advanced Biotechnology and Medicine, School of Public Health, Rutgers University, Piscataway, NJ 08854., Carson JL; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901., Panettieri RA Jr; Rutgers Institute for Translational Medicine & Science, New Brunswick, NJ 08901., Lardizabal A; Global Tuberculosis Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Chang TL; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Pinter A; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103., Gennaro ML; Public Health Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2021 May 12. Date of Electronic Publication: 2021 May 12.
DOI: 10.1101/2021.04.11.21255153
Abstrakt: Much is to be learned about the interface between immune responses to SARS-CoV-2 infection and vaccination. We monitored immune responses specific to SARS-CoV-2 Spike Receptor-Binding-Domain (RBD) in convalescent individuals for eight months after infection diagnosis and following vaccination. Over time, neutralizing antibody responses, which are predominantly RBD specific, generally decreased, while RBD-specific memory B cells persisted. RBD-specific antibody and B cell responses to vaccination were more vigorous than those elicited by infection in the same subjects or by vaccination in infection-naïve comparators. Notably, the frequencies of double negative B memory cells, which are dysfunctional and potentially pathogenic, increased in the convalescent subjects over time. Unexpectedly, this effect was reversed by vaccination. Our work identifies a novel aspect of immune dysfunction in mild/moderate COVID-19, supports the practice of offering SARS-CoV-2 vaccination regardless of infection history, and provides a potential mechanistic explanation for the vaccination-induced reduction of "Long-COVID" symptoms.
Databáze: MEDLINE
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