A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study.

Autor:	Rossi A; Unit of Dermatology, Sapienza University, Rome, Italy - alfredo.rossi@uniroma1.it., Magri F; Unit of Dermatology, Sapienza University, Rome, Italy., DI Fraia M; Unit of Dermatology, Sapienza University, Rome, Italy., Caro G; Unit of Dermatology, Sapienza University, Rome, Italy., Fortuna MC; Unit of Dermatology, Sapienza University, Rome, Italy., Piacentini M; Eurofins Cosmetics & Personal Care, Rome, Italy., Celleno L; Sacred Heart Catholic University, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Italian journal of dermatology and venereology [Ital J Dermatol Venerol] 2022 Feb; Vol. 157 (1), pp. 78-83. Date of Electronic Publication: 2021 Apr 21.
DOI:	10.23736/S2784-8671.21.06915-7
Abstrakt:	Background: Androgenetic alopecia (AGA) is the most frequent form of alopecia. Telogen effluvium (TE) is a common form of diffuse hair loss mainly observed in women. The aim of our study was to evaluate the efficacy of a topical trichological treatment containing a new combination of molecules for the treatment of AGA and TE. Methods: In-vitro tests were performed analyzing different combinations and concentrations of arginine, zinc and a third enzymatically neutral substance called AA on human follicles dermal papillae cells. These tests evaluated the capability of inhibiting the 5α-reductase (5-AR) enzyme and the 5-AR gene expression. We also performed an in-vivo study. Forty individuals affected by AGA and TE were divided into two groups. One group was administered a combination of zinc and arginine (lotion A), whilst the other placebo (lotion B). Therapy duration was 23 consecutive weeks. Follow-up examinations and pull tests occurred at baseline, after 6 weeks and at the end of the therapy. On 20 randomly selected patients we also performed noninvasive phototrichograms. Results: In-vitro tests showed that the combination had a strong statistically significant inhibitory activity on 5-AR of dermal papillae cells. Number of hairs removed by pull-test significantly decreased at T0, T1 and T2 in patient treated with lotion A. We also observed an increase in the percentage of anagen hair and a decrease in telogen hairs. Concerning phototrichograms, all objective parameters evaluated showed better results in the lotion A group when compared with the placebo group. Conclusions: Based on our results, the combination of arginine and zinc tested in our study could represent a good therapeutic option for the treatment of AGA and TE and it might represent a valid alternative to finasteride.
Databáze:	MEDLINE
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