Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats.

Autor:	Lasisi TJ; Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Oral Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Shittu ST; Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Abeje JI; Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ogunremi KJ; Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Shittu SA; Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Jazyk:	angličtina
Zdroj:	Journal of basic and clinical physiology and pharmacology [J Basic Clin Physiol Pharmacol] 2021 Apr 19; Vol. 33 (4), pp. 399-408. Date of Electronic Publication: 2021 Apr 19.
DOI:	10.1515/jbcpp-2020-0178
Abstrakt:	Objectives: Paradoxical sleep deprivation has been associated with impaired salivary secretion in rats. However, the mechanism that underlies this is not known. Therefore, this study assessed salivary and serum oxidative stress levels following paradoxical sleep deprivation in rats. Methods: Twenty-one male Wistar rats randomly divided into three groups of seven rats each as; Control (C); partial sleep-deprived (PSD); and total sleep-deprived (TSD) were used. Malondialdehyde (MDA) concentration, Superoxide dismutase (SOD), and catalase activities were evaluated in saliva, serum, and submandibular glands after seven days of sleep deprivation. Data were expressed as mean ± standard error of the mean and analyzed using one-way ANOVA, Tukey HSD post hoc, and Pearson's correlation tests. Results: Serum MDA levels were significantly higher in both the TSD and PSD groups compared to the control group whereas only the TSD group showed higher submandibular MDA levels compared to the PSD group and the control group. Submandibular SOD activity was significantly lower in both the TSD and PSD groups compared to the control group. Serum catalase activity was significantly lower in the TSD group only compared to the control group. Conclusions: These results have demonstrated for the first time that paradoxical sleep deprivation was associated with changes in the oxidant/antioxidant defense system in the submandibular salivary glands of male Wistar rats which may contribute to impairment in salivary secretion. (© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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