Composition and function of ciliary inner-dynein-arm subunits studied in Chlamydomonas reinhardtii.

Autor: Yamamoto R; Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka, Japan., Hwang J; Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA., Ishikawa T; Department of Biology and Chemistry, Paul Scherrer Institute, Villigen PSI, Switzerland.; Department of Biology, ETH Zurich, Zurich, Switzerland., Kon T; Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka, Japan., Sale WS; Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Cytoskeleton (Hoboken, N.J.) [Cytoskeleton (Hoboken)] 2021 Mar; Vol. 78 (3), pp. 77-96. Date of Electronic Publication: 2021 Apr 28.
DOI: 10.1002/cm.21662
Abstrakt: Motile cilia (also interchangeably called "flagella") are conserved organelles extending from the surface of many animal cells and play essential functions in eukaryotes, including cell motility and environmental sensing. Large motor complexes, the ciliary dyneins, are present on ciliary outer-doublet microtubules and drive movement of cilia. Ciliary dyneins are classified into two general types: the outer dynein arms (ODAs) and the inner dynein arms (IDAs). While ODAs are important for generation of force and regulation of ciliary beat frequency, IDAs are essential for control of the size and shape of the bend, features collectively referred to as waveform. Also, recent studies have revealed unexpected links between IDA components and human diseases. In spite of their importance, studies on IDAs have been difficult since they are very complex and composed for several types of IDA motors, each unique in composition and location in the axoneme. Thanks in part to genetic, biochemical, and structural analysis of Chlamydomonas reinhardtii, we are beginning to understand the organization and function of the ciliary IDAs. In this review, we summarize the composition of Chlamydomonas IDAs particularly focusing on each subunit, and discuss the assembly, conservation, and functional role(s) of these IDA subunits. Furthermore, we raise several additional questions/challenges regarding IDAs, and discuss future perspectives of IDA studies.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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