Spinal anesthesia in a patient on monoclonal antibody treatment: a poisoned chalice? A case report.
| Autor: | Herijgers A; Anesthesiology, KUL UZ Gasthuisberg, Leuven, Belgium., Van Dyck L; Anesthesiology, KUL UZ Gasthuisberg, Leuven, Belgium., Leroy I; Anesthesiology, Imeldaziekenhuis, Bonheiden, Belgium., Dobbels L; Neurology, Imeldaziekenhuis, Bonheiden, Belgium., Van de Putte PBC; Anesthesiology, Imeldaziekenhuis, Bonheiden, Belgium doktervdputte@gmail.com. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Regional anesthesia and pain medicine [Reg Anesth Pain Med] 2021 Sep; Vol. 46 (9), pp. 828-830. Date of Electronic Publication: 2021 Apr 19. |
| DOI: | 10.1136/rapm-2021-102557 |
| Abstrakt: | Background: Paraplegia is a rare complication of spinal anesthesia. Case Presentation: We report a case of a 68-year-old man who developed postoperative paraplegia and hypoesthesia after spinal anesthesia for an otherwise uncomplicated transurethral resection of the prostate. Acute transverse myelitis was diagnosed based on urgent MRI. A prior history of similar though less severe neurological symptoms after obinutuzumab treatment for follicular lymphoma suggested a potential causative role for obinutuzumab, a novel monoclonal antibody that has not been associated with such devastating neurological side effects yet. High-dose steroid treatment partially attenuated the symptoms, but debilitating hypoesthesia and motor deficit remained present 3 months postoperatively. Conclusion: The presented case warrants caution when performing neuraxial anesthesia in patients on monoclonal antibody therapies. Competing Interests: Competing interests: None declared. (© American Society of Regional Anesthesia & Pain Medicine 2021. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|