Cardiovascular Risk Factors are Associated with Future Cancer.

Autor:	Lau ES; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Paniagua SM; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts., Liu E; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Jovani M; Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland., Li SX; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Takvorian K; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Suthahar N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Cheng S; Department of Cardiology, Cedars Sinai Medical Center, Los Angeles, California., Splansky GL; Framingham Heart Study, Framingham, Massachusetts., Januzzi JL Jr; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Wang TJ; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Vasan RS; Framingham Heart Study, Framingham, Massachusetts.; Cardiovascular Medicine Section, Department of Medicine ad Section of Preventive Medicine and Epidemiology, Boston University School of Public Health, Boston, Massachusetts.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts., Kreger B; Cardiovascular Medicine Section, Department of Medicine ad Section of Preventive Medicine and Epidemiology, Boston University School of Public Health, Boston, Massachusetts., Larson MG; Framingham Heart Study, Framingham, Massachusetts.; Department of Mathematics and Statistics, Boston University, Boston, Massachusetts., Levy D; Framingham Heart Study, Framingham, Massachusetts.; Center for Population Studies of the National Heart, Lung, and Blood Institute, Bethesda, Maryland., de Boer RA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ho JE; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Jazyk:	angličtina
Zdroj:	JACC. CardioOncology [JACC CardioOncol] 2021 Mar; Vol. 3 (1), pp. 48-58. Date of Electronic Publication: 2021 Mar 16.
DOI:	10.1016/j.jaccao.2020.12.003
Abstrakt:	Background: The extent to which co-occurrence of cardiovascular disease (CVD) and cancer is due to shared risk factors or other mechanisms is unknown. Objectives: We investigated the association of standard CVD risk factors, CVD biomarkers, preexisting CVD, and ideal CV health metrics with the development of future cancer. Methods: We prospectively followed Framingham Heart Study and PREVEND participants free of cancer at baseline, and ascertained histology-proven cancer. We studied the association of baseline CV risk factors, 10-year atherosclerotic CVD risk score, established CVD biomarkers, prevalent CVD, and AHA Life's Simple 7 CV health score with incident cancer using multivariable Cox models. Analyses of interim CVD events with incident cancer used time-dependent covariates. Results: Among 20,305 participants (mean age 50 ± 14 years, 54% women), 2,548 incident cancer cases occurred over a median follow-up of 15.0 (13.3-15.0) surveillance years. Traditional CVD risk factors including age, sex, and smoking status were independently associated with cancer (P <0.001 for all). Estimated 10-year atherosclerotic CVD risk was also associated with future cancer (HR 1.16 per 5% increase in risk, 95% CI 1.14-1.17, P<0.001). We found that natriuretic peptides (NP) (tertile 3 vs 1: HR 1.40, 95% CI 1.03-1.91, p=0.035) was associated with incident cancer, but not high sensitivity troponin (hs-cTn) (p=0.47). Prevalent CVD and the development of interim CV events were not associated with higher risk of subsequent cancer. However, ideal CV health was associated with lower future cancer risk (HR 0.95 per 1-point increase in AHA health score, 95% CI 0.92-0.99, p=0.009). Conclusions: CVD risk as captured by traditional CVD risk factors, 10-year atherosclerotic CVD risk score, and NP concentrations are associated with increased risk of future cancer. Conversely, a heart healthy lifestyle is associated with a reduced risk of future cancer. Our data suggest that the association between CVD and future cancer is attributable to shared risk factors.
Databáze:	MEDLINE
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