In vitro and in vivo evaluation of the wound healing properties and safety assessment of two seaweeds ( Sargassum ilicifolium and Ulva lactuca ).

Autor:	Premarathna AD; Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka.; School of Natural Sciences and Health, Tallinn University, Narva mnt 29, 10120, Tallinn, Estonia., Wijesekera SK; Department of Zoology, Faculty of Natural Sciences, Open University, Kandy Regional Center, Polgolla, Sri Lanka., Jayasooriya AP; Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka., Waduge RN; Department of Pathobiology, Faculty of Medicine, University of Peradeniya, Sri Lanka., Wijesundara RRMKK; Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka., Tuvikene R; School of Natural Sciences and Health, Tallinn University, Narva mnt 29, 10120, Tallinn, Estonia., Harishchandra DL; Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka., Ranahewa TH; Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka., Perera NAND; Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka., Wijewardana V; Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka.; International Atomic Energy Agency (IAEA), Vienna, Austria., Rajapakse RPVJ; Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka.
Jazyk:	angličtina
Zdroj:	Biochemistry and biophysics reports [Biochem Biophys Rep] 2021 Mar 31; Vol. 26, pp. 100986. Date of Electronic Publication: 2021 Mar 31 (Print Publication: 2021).
DOI:	10.1016/j.bbrep.2021.100986
Abstrakt:	Seaweeds have been regarded as a reservoir of biologically active molecules that are important in the pharmaceutical industry. The aim of the present study was to explore the wound healing properties and to assess the safety of the seaweed Sargassum ilicifolium and Ulva lactuca. Enhanced cell proliferation and cell migration activities were observed in L929 cells treated with S. ilicifolium extract compared to U. lactuca extract treated cells and the control group. In-vivo experiments were conducted using five groups (10 in each) of Albino mice (BALB/c). Mice in group I and group II were treated (Orally, 100 mg/kg BW/day) with aqueous extracts of S. ilicifolium and U. lactuca , respectively for 14 days. Treatment group III received a topical application of the aqueous extract of S. ilicifolium (25% w/w) and ointment base (75% w/w) (2 g/kg BW/day, for 14 days). Group IV (Control) received an equal amount of distilled water, orally and mice in group V kept without wounds. The extract from S. ilicifolium showed stronger wound healing properties than the one from Ulva lactuca . Histopathological findings also revealed that the healing process was significantly enhanced in the mice group treated orally with S. ilicifolium aqueous extract. These findings show that S. ilicifolium species possess promising wound healing properties in-vitro and in-vivo . Competing Interests: The author(s) declare that they have no competing interests. (© 2021 Published by Elsevier B.V.)
Databáze:	MEDLINE
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