Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology.
| Autor: | Blagih J; The Francis Crick Institute, London, United Kingdom., Hennequart M; The Francis Crick Institute, London, United Kingdom., Zani F; The Francis Crick Institute, London, United Kingdom. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in immunology [Front Immunol] 2021 Apr 02; Vol. 12, pp. 637960. Date of Electronic Publication: 2021 Apr 02 (Print Publication: 2021). |
| DOI: | 10.3389/fimmu.2021.637960 |
| Abstrakt: | Regulatory T cells (Tregs) are essential for mitigating inflammation. Tregs are found in nearly every tissue and play either beneficial or harmful roles in the host. The availability of various nutrients can either enhance or impair Treg function. Mitochondrial oxidative metabolism plays a major role in supporting Treg differentiation and fitness. While Tregs rely heavily on oxidation of fatty acids to support mitochondrial activity, they have found ways to adapt to different tissue types, such as tumors, to survive in competitive environments. In addition, metabolic by-products from commensal organisms in the gut also have a profound impact on Treg differentiation. In this review, we will focus on the core metabolic pathways engaged in Tregs, especially in the context of tissue nutrient environments, and how they can affect Treg function, stability and differentiation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Blagih, Hennequart and Zani.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|