Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression.

Autor: Asl ER; Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Amini M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Najafi S; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Mansoori B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran., Mokhtarzadeh A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Mohammadi A; Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark., Lotfinejad P; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences., Bagheri M; Department of Biology, Khorasan Razavi Science and Research Branch, Islamic Azad University, Neyshabur, Iran., Shirjang S; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Lotfi Z; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Rasmi Y; Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.. Electronic address: rasmiy@umsu.ac.ir., Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.. Electronic address: baradaranb@tbzmed.ac.ir.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119499. Date of Electronic Publication: 2021 Apr 15.
DOI: 10.1016/j.lfs.2021.119499
Abstrakt: Mitogen-activated protein kinase (MAPK) signal transduction, as a highly conserved signaling pathway, is reported to be involved in various biological events, including metabolic reprogramming, cell proliferation, survival, and differentiation. Mutations in key molecules involved in MAPK/ERK signaling and dysregulation of this pathway are very common events in various human malignancies, which make the MAPK signaling a crucial signaling pathway participating in the regulation of glucose uptake by malignant cells and tumorigenesis. MicroRNAs (miRNAs), as small non-coding RNAs, are critical regulators of gene expression that play key roles in cancer initiation and progression. On the other hand, these small RNAs mutually regulate the MAPK signaling which is often overexpressed in the case of cancer progression; suggesting that crosstalk between miRNAs and this signaling pathway plays a pivotal role in the development of human cancers. Some miRNAs such as miR-20b, miR-34c-3p, miR-152, miR-181a, and miR-302b through inhibiting MAPK signaling, and miR-193a-3p, miR-330-3p, and miR-592 by activating this signaling pathway, play imperative roles in tumorigenesis. Therefore, in this review, we aimed to focus on the interplay between miRNAs and MAPK signaling in the various steps of tumorigenesis, including metabolic regulation, cell proliferation, apoptosis, metastasis, angiogenesis, and drug resistance.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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