Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.

Autor: McWhinney SR; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Abé C; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Alda M; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Benedetti F; Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Bøen E; Unit for Psychosomatics / CL Outpatient Clinic for Adults, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Del Mar Bonnin C; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Borgers T; Department of Psychiatry, University of Münster, Münster, Germany., Brosch K; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Canales-Rodríguez EJ; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain., Cannon DM; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Dannlowski U; Department of Psychiatry, University of Münster, Münster, Germany., Díaz-Zuluaga AM; Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Elvsåshagen T; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Eyler LT; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.; Desert-Pacific MIRECC, VA San Diego Healthcare, San Diego, CA, USA., Fullerton JM; Neuroscience Research Australia, Randwick, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Goikolea JM; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Goltermann J; Department of Psychiatry, University of Münster, Münster, Germany., Grotegerd D; Department of Psychiatry, University of Münster, Münster, Germany., Haarman BCM; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Hahn T; Department of Psychiatry, University of Münster, Münster, Germany., Howells FM; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Ingvar M; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Kircher TTJ; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Krug A; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Kuplicki RT; Laureate Institute for Brain Research, Tulsa, OK, USA., Landén M; Department of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lemke H; Department of Psychiatry, University of Münster, Münster, Germany., Liberg B; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Lopez-Jaramillo C; Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Malt UF; Unit for Psychosomatics / CL Outpatient Clinic for Adults, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Department of Neurology, University of Oslo, Oslo, Norway., Martyn FM; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Mazza E; Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., McDonald C; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., McPhilemy G; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Meier S; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Meinert S; Department of Psychiatry, University of Münster, Münster, Germany., Meller T; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg, Germany., Melloni EMT; Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Mitchell PB; School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Nabulsi L; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Nenadic I; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Opel N; Department of Psychiatry, University of Münster, Münster, Germany., Ophoff RA; UCLA Center for Neurobehavioral Genetics, Los Angeles, CA, USA.; Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands., Overs BJ; Neuroscience Research Australia, Randwick, NSW, Australia., Pfarr JK; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Pineda-Zapata JA; Research Group, Instituto de Alta Tecnología Médica, Ayudas diagnósticas SURA, Medellín, Colombia., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain., Raduà J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.; Institute of Psychiartry, King's College Londen, London, UK., Repple J; Department of Psychiatry, University of Münster, Münster, Germany., Richter M; Department of Psychiatry, University of Münster, Münster, Germany., Ringwald KG; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Roberts G; School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain., Savitz J; Laureate Institute for Brain Research, Tulsa, OK, USA.; Oxley College of Health Sciences, The University of Tulsa, Tulsa, OK, USA., Schmitt S; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Schofield PR; Neuroscience Research Australia, Randwick, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Sim K; West Region, Institute of Mental Health, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Stein DJ; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.; South African MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa., Stein F; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Temmingh HS; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Thiel K; Department of Psychiatry, University of Münster, Münster, Germany., van Haren NEM; Department of Child and Adolescent Psychiatry and Psychology, Erasmus University, Rotterdam, The Netherlands.; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Gestel HV; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Vargas C; Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Vieta E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Vreeker A; Department of Child and Adolescent Psychiatry and Psychology, Erasmus University, Rotterdam, The Netherlands., Waltemate L; Department of Psychiatry, University of Münster, Münster, Germany., Yatham LN; University of British Columbia, Vancouver, BC, Canada., Ching CRK; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Andreassen O; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Hajek T; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. tomas.hajek@dal.ca.; National Institute of Mental Health, Klecany, Czech Republic. tomas.hajek@dal.ca.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2021 Nov; Vol. 26 (11), pp. 6806-6819. Date of Electronic Publication: 2021 Apr 16.
DOI: 10.1038/s41380-021-01098-x
Abstrakt: Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles  and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
(© 2021. The Author(s).)
Databáze: MEDLINE
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